Abstract：
To determine the prevalence of signs and symptoms of HTLV-1 and 2 infection in paediatric patients.
We included cohort, case-control and descriptive observational studies that reported the prevalence of signs and symptoms of HTLV-1 and 2 infections in paediatric patients. Searches were performed in MEDLINE® (Ovid), EMBASE and LILACS from inception to the present, and we saturated information with other sources of published and unpublished literature. We decided not to perform meta-analysis according to heterogeneity.
A total of eight studies met the inclusion criteria for qualitative analysis. No studies of HTLV-2 were found. Females predominated and there was vertical transmission in nearly 100% of cases. Infective dermatitis was a common manifestation of HTLV in paediatric patients. In addition, persistent hyperreflexia, clonus and the Babinski sign were early neurological alterations observed in patients carrying the virus.
HTLV screening is recommended in patients presenting infective dermatitis, persistent hyperreflexia, walking disturbances and in those who come from endemic zones.
We included cohort, case-control and descriptive observational studies that reported the prevalence of signs and symptoms of HTLV-1 and 2 infections in paediatric patients. Searches were performed in MEDLINE® (Ovid), EMBASE and LILACS from inception to the present, and we saturated information with other sources of published and unpublished literature. We decided not to perform meta-analysis according to heterogeneity.
A total of eight studies met the inclusion criteria for qualitative analysis. No studies of HTLV-2 were found. Females predominated and there was vertical transmission in nearly 100% of cases. Infective dermatitis was a common manifestation of HTLV in paediatric patients. In addition, persistent hyperreflexia, clonus and the Babinski sign were early neurological alterations observed in patients carrying the virus.
HTLV screening is recommended in patients presenting infective dermatitis, persistent hyperreflexia, walking disturbances and in those who come from endemic zones.
摘要：
目的：确定儿科患者HTLV-1和2感染的体征和症状的患病率。
方法：我们包括队列，病例对照和描述性观察性研究报告了儿科患者中HTLV-1和2感染的体征和症状的患病率。在MEDLINE®(Ovid)中进行搜索，EMBASE和LILACS从成立到现在，我们用其他已发表和未发表的文献来源饱和了信息。我们决定不根据异质性进行荟萃分析。
结果：共有8项研究符合定性分析的纳入标准。没有发现HTLV-2的研究。女性占主导地位，在近100％的病例中有垂直传播。感染性皮炎是儿科患者HTLV的常见表现。此外,持续性反射亢进,Clonus和Babinski标志是在携带病毒的患者中观察到的早期神经系统改变。
结论：建议对出现感染性皮炎的患者进行HTLV筛查，持续性反射亢进,行走障碍和来自流行区的人。
方法：我们包括队列，病例对照和描述性观察性研究报告了儿科患者中HTLV-1和2感染的体征和症状的患病率。在MEDLINE®(Ovid)中进行搜索，EMBASE和LILACS从成立到现在，我们用其他已发表和未发表的文献来源饱和了信息。我们决定不根据异质性进行荟萃分析。
结果：共有8项研究符合定性分析的纳入标准。没有发现HTLV-2的研究。女性占主导地位，在近100％的病例中有垂直传播。感染性皮炎是儿科患者HTLV的常见表现。此外,持续性反射亢进,Clonus和Babinski标志是在携带病毒的患者中观察到的早期神经系统改变。
结论：建议对出现感染性皮炎的患者进行HTLV筛查，持续性反射亢进,行走障碍和来自流行区的人。
