METHODS: We retrospectively collected data on 3,014 lesions from 2,022 consecutive patients, who underwent EES implantation at Koto Memorial Hospital. Atherogenic dyslipidemia (AD) is defined as a combination of non-fasting serum TG ≥ 175 mg/dL and HDL-C <40 mg/dL.
RESULTS: AD was observed in 212 lesions in 139 (6.9%) patients. The cumulative incidence of clinically driven TLR was significantly higher in patients with AD than in those without AD (hazard ratio [HR] 2.31, 95% confidence interval [CI] 1.43-3.73, P=0.0006). Subgroup analysis showed that AD increased the risk of TLR with the implantation of small stents (≤ 2.75 mm). Multivariable Cox regression analysis showed that AD was an independent predictor of TLR in the small EES stratum (adjusted HR 3.00, 95% CI 1.53-5.93, P=0.004), whereas the incidence of TLR was similar in the non-small-EES stratum, irrespective of the presence or absence of AD.
CONCLUSIONS: Patients with AD had a higher risk of TLR after EES implantation, and this risk was greater for lesions treated with small stents.
方法:我们回顾性收集了2,022例连续患者的3,014个病灶的数据,他在Koto纪念医院接受了EES植入。动脉粥样硬化血脂异常(AD)定义为非空腹血清TG≥175mg/dL和HDL-C<40mg/dL。
结果:在139例(6.9%)患者的212个病灶中观察到AD。AD患者临床驱动的TLR的累积发生率明显高于无AD患者(风险比[HR]2.31,95%置信区间[CI]1.43-3.73,P=0.0006)。亚组分析显示,AD随着小支架(≤2.75mm)的植入而增加TLR的风险。多变量Cox回归分析显示AD是小EES层TLR的独立预测因子(校正HR3.00,95%CI1.53~5.93,P=0.004),而TLR在非小EES层的发生率相似,无论是否存在AD。
结论:AD患者在EES植入后发生TLR的风险更高,对于小支架治疗的病变,这种风险更大。