Abstract：
Evidence suggests that ventilation during ex vivo lung perfusion (EVLP) with a \'one-size-fits-all\' strategy has the potential to cause lung injury which may only become clinically relevant in marginal lung allografts. EVLP induced- or accelerated lung injury is a dynamic and cumulative process reflecting the interplay of a number of factors. Stress and strain in lung tissue caused by positive pressure ventilation may be exacerbated by the altered properties of lung tissue in an EVLP setting. Any pre-existing injury may alter the ability of lung allografts to accommodate set ventilation and perfusion techniques on EVLP leading to further injury. This review will examine the effects of ventilation on donor lungs in the setting of EVLP. A framework for developing a protective ventilation technique will be proposed.
摘要：
有证据表明，采用“一刀切”策略的离体肺灌注（EVLP）通气可能会引起肺损伤，而肺损伤可能仅在边缘肺同种异体移植物中具有临床意义。EVLP诱导或加速的肺损伤是反映许多因素相互作用的动态和累积过程。由正压通气引起的肺组织中的应力和应变可能因EVLP设置中的肺组织的性质改变而加剧。任何先前存在的损伤可能会改变肺同种异体移植物适应EVLP上设定的通气和灌注技术的能力，从而导致进一步的损伤。这篇综述将研究在EVLP设置中通气对供体肺的影响。将提出开发保护性通风技术的框架。
