Abstract：
Brucellosis is one of the most common zoonosis worldwide, affecting 500 000 people, annually. Neurobrucellosis incidence is approximately 4%, and it is almost always heterogeneous. As there are no typical clinical features, its diagnosis is frequently misdiagnosing by other infections.
Neurobrucellosis picture includes meningitis, meningoencephalitis, encephalitis, cranial neuropathies, intracranial hypertension, sinus thrombosis, hemorrhages radiculitis, peripheral neuropathy, myelitis, and psychiatric manifestations. The diagnosis should be based on symptoms and signs suggestive of neurobrucellosis, not explained by other neurological disease, cerebrospinal fluid analysis, a positive Brucella serology or culture, and a response to specific antibiotics, with a significant improvement of cerebrospinal fluid parameters.
Neurobrucellosis can be insidious, and despite its global distribution, it is still unrecognized and frequently goes unreported. The understanding of the current epidemiology is necessary for eradication of the disease in humans, as well as the disease control in animals and prevention based on occupational hygiene and food hygiene.
Neurobrucellosis picture includes meningitis, meningoencephalitis, encephalitis, cranial neuropathies, intracranial hypertension, sinus thrombosis, hemorrhages radiculitis, peripheral neuropathy, myelitis, and psychiatric manifestations. The diagnosis should be based on symptoms and signs suggestive of neurobrucellosis, not explained by other neurological disease, cerebrospinal fluid analysis, a positive Brucella serology or culture, and a response to specific antibiotics, with a significant improvement of cerebrospinal fluid parameters.
Neurobrucellosis can be insidious, and despite its global distribution, it is still unrecognized and frequently goes unreported. The understanding of the current epidemiology is necessary for eradication of the disease in humans, as well as the disease control in animals and prevention based on occupational hygiene and food hygiene.
摘要：
目的：布鲁氏菌病是世界范围内最常见的人畜共患病之一，影响了50万人，每年。神经布鲁氏菌病发病率约为4%，它几乎总是异质的。由于没有典型的临床特征，它的诊断经常被其他感染误诊。
结果：神经布鲁氏菌病图片包括脑膜炎，脑膜脑炎,脑炎,颅神经病,颅内高压,窦血栓形成,出血性神经根炎,周围神经病变,脊髓炎,和精神病表现。诊断应基于提示神经布鲁氏菌病的症状和体征，不能用其他神经疾病来解释，脑脊液分析,布鲁氏菌血清学或培养阳性，以及对特定抗生素的反应，脑脊液参数有显著改善。
结论：神经布鲁氏菌病可能是阴险的，尽管它分布在全球，它仍然没有被识别，经常没有报告。了解当前的流行病学对于根除人类疾病是必要的，以及基于职业卫生和食品卫生的动物疾病控制和预防。
结果：神经布鲁氏菌病图片包括脑膜炎，脑膜脑炎,脑炎,颅神经病,颅内高压,窦血栓形成,出血性神经根炎,周围神经病变,脊髓炎,和精神病表现。诊断应基于提示神经布鲁氏菌病的症状和体征，不能用其他神经疾病来解释，脑脊液分析,布鲁氏菌血清学或培养阳性，以及对特定抗生素的反应，脑脊液参数有显著改善。
结论：神经布鲁氏菌病可能是阴险的，尽管它分布在全球，它仍然没有被识别，经常没有报告。了解当前的流行病学对于根除人类疾病是必要的，以及基于职业卫生和食品卫生的动物疾病控制和预防。
