PDF(Pubmed)
Abstract：
Although the hippocampus is generally considered a cognitive center for spatial representation, learning, and memory, increasing evidence supports its roles in regulating locomotion. However, the neuronal mechanisms of the hippocampal regulation of locomotion and exploratory behavior remain unclear. In this study, we found that the inhibitory hippocampal synaptic projection to the medial septum (MS) bi-directionally controls the locomotor speed of mice. The activation of the MS-projecting interneurons in the hippocampus or the activation of the hippocampus-originated inhibitory synaptic terminals in the MS decreased locomotion and exploratory behavior. On the other hand, the inhibition of the hippocampus-originated inhibitory synaptic terminals in the MS increased locomotion. Unlike the septal projecting interneurons, the activation of the hippocampal interneurons projecting to the retrosplenial cortex did not change animal locomotion. Therefore, this study reveals a specific long-range inhibitory synaptic output from the hippocampus to the medial septum in the regulation of animal locomotion.
摘要：
尽管海马体通常被认为是空间表示的认知中心，学习,和记忆，越来越多的证据支持它在调节运动中的作用。然而,海马运动和探索行为调节的神经元机制仍不清楚。在这项研究中,我们发现，抑制性海马突触投射到内侧隔膜（MS）双向控制小鼠的运动速度。海马中MS投射中间神经元的激活或MS中海马起源的抑制性突触末端的激活降低了运动和探索行为。另一方面,MS中海马起源的抑制性突触末端的抑制增加了运动。与间隔突出的中间神经元不同，投射到脾后皮质的海马中间神经元的激活没有改变动物的运动。因此,这项研究揭示了在动物运动的调节中，从海马到内侧隔膜的特定长程抑制性突触输出。
