PDF(Pubmed)
Abstract：
Diabetes mellitus (DM) is a widespread metabolic disorder with a yearly 6.7 million deaths worldwide. Several treatment options are available but with common side effects like weight gain, cardiovascular diseases, neurotoxicity, hepatotoxicity, and nephrotoxicity. Therefore, ethnomedicine is gaining the interest of researchers in the treatment of DM. Ethnomedicine works by preventing intestinal absorption and hepatic production of glucose as well as enhancing glucose uptake in muscles and fatty tissues and increasing insulin secretion. A variety of plants have entered clinical trials but very few have gained approval for use. This current study provides an evaluation of such clinical trials. For this purpose, an extensive literature review was performed from a database using keywords like \"ethnomedicine diabetes clinical trial\", \"clinical trials\", \"clinical trial in diabetes\", \"diabetes\", \"natural products in diabetes\", \"ethno-pharmacological relevance of natural products in diabetes\", etc. Clinical trials of 20 plants and natural products were evaluated based on eligibility criteria. Major limitations associated with these clinical trials were a lack of patient compliance, dose-response relationship, and an evaluation of biomarkers with a small sample size and treatment duration. Measures in terms of strict regulations can be considered to achieve quality clinical trials. A specific goal of this systematic review is to discuss DM treatment through ethnomedicine based on recent clinical trials of the past 7 years.
摘要：
糖尿病（DM）是一种广泛的代谢紊乱，全球每年有670万人死亡。有几种治疗选择，但有常见的副作用，如体重增加，心血管疾病,神经毒性，肝毒性，和肾毒性。因此,民族医学正在引起研究人员对DM治疗的兴趣。民族医学通过防止肠道吸收和肝脏产生葡萄糖以及增强肌肉和脂肪组织中的葡萄糖摄取和增加胰岛素分泌来发挥作用。多种植物已经进入临床试验，但很少有植物获得批准使用。本研究提供了对此类临床试验的评估。为此,使用“民族医学糖尿病临床试验”等关键词从数据库中进行了广泛的文献综述，“临床试验”，“糖尿病临床试验”，\"糖尿病\",“糖尿病中的天然产物”，“天然产物与糖尿病的药理学相关性”，等。根据合格标准评估了20种植物和天然产物的临床试验。与这些临床试验相关的主要限制是缺乏患者依从性，剂量-反应关系，以及小样本量和治疗持续时间的生物标志物评估。可以考虑在严格的法规方面采取措施，以实现临床试验的质量。本系统综述的一个具体目标是根据过去7年的最新临床试验，通过种族医学讨论DM治疗。
