Abstract：
This study aimed to investigate the effect of maternal supplementation of L-carnosine on improved reflexive motor behaviors in mice offspring. Forty pregnant female NMRI mice were allocated into four groups. In the control group, mice received water, while in groups 2-4, female mice received supplementation of the L-carnosine (0.001, 0.01, or 0.1 mg/kg) at gestation days (G.D.) 5, 8, 11, 14, and 17. Newborn male pups were selected, and reflexive motor behaviors were analyzed on days 5, 7, 10, and 10-15, respectively. Serum malondialdehyde(MDA), superoxide dismutase(SOD), glutathione peroxidase(GPx) and total antioxidant status(TAS) of was determined in offspring\'s. According to findings, prenatal supplementation of the L-carnosine significantly increased ambulation score, surface righting, hind-limb suspension score, grip strength, front-limb suspension time, and negative geotaxis in mice offspring (P < 0.05). Hind-limb foot angle decreased in mice offspring by maternal supplementation of the L-carnosine (P < 0.05). Prenatal supplementation of the L-carnosine significantly decreased the MDA and increased the SOD, GPx, and TAS levels in offspring (P < 0.05). These results suggested maternal supplementation of the L-carnosine improved reflexive motor behaviors and antioxidant status in mice offspring.
摘要：
本研究旨在探讨母体补充L-肌肽对子代小鼠反身运动行为的改善作用。将40只怀孕的雌性NMRI小鼠分为四组。在对照组中，老鼠接受了水，而在第2-4组中,雌性小鼠在妊娠天数(G.D.)5、8、11、14和17时接受L-肌肽(0.001、0.01或0.1mg/kg)的补充。选择了新生雄性幼崽，和反身运动行为分别在第5、7、10和10-15天进行分析。血清丙二醛(MDA),超氧化物歧化酶（SOD），在后代中测定了谷胱甘肽过氧化物酶（GPx）和总抗氧化状态（TAS）。根据调查结果,产前补充L-肌肽可显着增加步行评分，表面扶正,后肢悬吊评分,握力,前肢悬挂时间,小鼠子代地基运动负向(P<0.05)。母亲补充L-肌肽后，小鼠后肢足角度降低（P<0.05）。产前补充L-肌肽能显著降低MDA,升高SOD,GPx,子代TAS水平(P<0.05)。这些结果表明母亲补充L-肌肽改善了小鼠后代的反射运动行为和抗氧化状态。
