Abstract：
Heart failure with preserved ejection fraction is a growing public health concern, a disease with poor health outcomes, and is showing increased prevalence globally. This review paper explores the literature with a focus on the pathophysiology and microbiology of preserved ejection fraction heart failure while drawing connections between preserved and reduced ejection fraction states. The discussion teases out the cellular level changes that affect the overall dysfunction of the cardiac tissue, including the clinical manifestations, microbiological changes (endothelial cells, fibroblasts, cardiomyocytes, and excitation-contraction coupling), and the burden of structural diastolic dysfunction. The goal of this review is to summarize the pathophysiological disease state of heart failure with preserved ejection fraction to enhance understanding, knowledge, current treatment models of this pathology.
摘要：
射血分数保留的心力衰竭是一个日益增长的公共卫生问题，一种健康状况不佳的疾病，并显示全球患病率增加。这篇综述论文探讨了文献，重点是保留的射血分数心力衰竭的病理生理学和微生物学，同时在保留的射血分数状态和降低的射血分数状态之间建立联系。讨论梳理了影响心脏组织整体功能障碍的细胞水平变化，包括临床表现，微生物变化（内皮细胞，成纤维细胞,心肌细胞，和激励-收缩耦合)，和结构性舒张功能障碍的负担。这篇综述的目的是总结射血分数保留的心力衰竭的病理生理疾病状态，以提高人们的认识。知识,目前这种病理的治疗模式。
