PDF(Pubmed)
Abstract：
The extracellular matrix (ECM) is an intricate network composed of various multi-domain macromolecules like collagen, proteoglycans, and fibronectin, etc., that form a structurally stable composite, contributing to the mechanical properties of tissue. However, matricellular proteins are non-structural, secretory extracellular matrix proteins, which modulate various cellular functions via interacting with cell surface receptors, proteases, hormones, and cell-matrix. They play essential roles in maintaining tissue homeostasis by regulating cell differentiation, proliferation, adhesion, migration, and several signal transduction pathways. Matricellular proteins display a broad functionality regulated by their multiple structural domains and their ability to interact with different extracellular substrates and/or cell surface receptors. The expression of these proteins is low in adults, however, gets upregulated following injuries, inflammation, and during tumor growth. The marked elevation in the expression of these proteins during atherosclerosis suggests a positive association between their expression and atherosclerotic lesion formation. The role of matricellular proteins in atherosclerosis development has remained an area of research interest in the last two decades and studies revealed these proteins as important players in governing vascular function, remodeling, and plaque formation. Despite extensive research, many aspects of the matrix protein biology in atherosclerosis are still unknown and future studies are required to investigate whether targeting pathways stimulated by these proteins represent viable therapeutic approaches for patients with atherosclerotic vascular diseases. This review summarizes the characteristics of distinct matricellular proteins, discusses the available literature on the involvement of matrix proteins in the pathogenesis of atherosclerosis and suggests new avenues for future research.
摘要：
细胞外基质（ECM）是一个复杂的网络，由多种多域大分子组成，如胶原蛋白，蛋白聚糖,和纤连蛋白,等。,形成结构稳定的复合材料，有助于组织的机械性能。然而,体细胞蛋白是非结构性的，分泌细胞外基质蛋白，通过与细胞表面受体相互作用来调节各种细胞功能，蛋白酶，荷尔蒙，和细胞基质。它们通过调节细胞分化在维持组织稳态中发挥重要作用，扩散,附着力,迁移,以及几种信号转导途径。基质细胞蛋白显示出受其多个结构域调节的广泛功能性以及其与不同的细胞外底物和/或细胞表面受体相互作用的能力。这些蛋白质在成人中的表达很低，然而,受伤后被上调，炎症,在肿瘤生长过程中。动脉粥样硬化过程中这些蛋白质表达的显着升高表明它们的表达与动脉粥样硬化病变形成之间存在正相关。在过去的二十年中，基质细胞蛋白在动脉粥样硬化发展中的作用仍然是一个研究兴趣的领域，研究表明这些蛋白是控制血管功能的重要参与者。重塑，和斑块形成。尽管进行了广泛的研究,动脉粥样硬化中基质蛋白生物学的许多方面仍然未知,需要进一步的研究来研究这些蛋白刺激的靶向途径是否代表动脉粥样硬化血管疾病患者的可行治疗方法.这篇综述总结了不同基质细胞蛋白的特征，讨论了有关基质蛋白参与动脉粥样硬化发病机理的现有文献，并为未来的研究提供了新的途径。
