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Abstract：
The term autophagy describes a process that supports nutrient cycling and metabolic adaptation that is accomplished via multistep lysosomal degradation. These activities modulate cell, tissue and internal environment stability, and can also affect the occurrence and development of cancer. Previous studies have mostly described autophagy as having dual effects in cancer, serving to limit tumorigenesis in the early stages of cancer, but promoting tumor progression in certain types of cancer. There have been indications in recent years that microRNAs (miRNAs/miRs) and long non‑coding RNAs (lncRNAs), as types of non‑coding RNAs, play major roles in the occurrence, invasion, development and drug resistance of hepatocellular carcinoma (HCC) and in the migration of HCC cells by governing HCC cell autophagy. Therefore, understanding which miRNAs and lncRNAs play such roles and the relevant molecular mechanisms is critical. The present review highlights the significant functions of miRNAs and lncRNAs in the regulation of autophagy in HCC and the relevant mechanisms, aiming to provide novel insight into HCC therapeutics.
摘要：
术语自噬描述了支持通过多步溶酶体降解实现的营养循环和代谢适应的过程。这些活动调节细胞，组织和内部环境的稳定性，还可以影响癌症的发生和发展。以前的研究大多描述自噬在癌症中具有双重作用，用于限制癌症早期阶段的肿瘤发生，而是促进某些类型癌症的肿瘤进展。近年来有迹象表明，microRNAs（miRNAs/miRs）和长链非编码RNAs（lncRNAs），作为非编码RNA的类型，在发生中起主要作用，入侵,肝细胞癌（HCC）的发展和耐药性以及通过控制HCC细胞自噬在HCC细胞迁移中的作用。因此,了解miRNAs和lncRNAs发挥这种作用以及相关的分子机制至关重要。本文综述了miRNAs和lncRNAs在肝癌自噬调控中的重要作用及其相关机制。旨在为肝癌治疗提供新的见解。
