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Abstract：
Langerhans cell histiocytosis (LCH), earlier recognised as histiocytosis X, is a rare haematological illness involving infants and young children. LCH is caused by unrestrained stimulation and proliferation of usual antigen presenting cells, Langerhans cells (LCs) and the disease demonstrates extensive clinical and radiographic features involving multiple sites. Since the incidence is relatively low limited data is available regarding the epidemiology of LCH, with approximation of 2-5 cases per million populations per year. LCH has male predilection with jaws involved in 10-20% cases and only 1% of the cases affecting maxilla, masquerading as periodontal or periapical pathology. We report a case of 48-year-old female with LCH involving posterior maxilla. This is a unique presentation corresponding to age, gender, location and severity. Dental clinicians should be aware of this and consider it to be a part of their differential diagnosis pertaining to unresolved periodontal pathology as it mimics clinically and radiographically.
摘要：
朗格汉斯细胞组织细胞增生症(LCH),早期被认为是组织细胞增生症X，是一种罕见的血液病，涉及婴幼儿。LCH是由通常的抗原呈递细胞的无限制刺激和增殖引起的，朗格汉斯细胞（LC）和疾病表现出涉及多个部位的广泛的临床和放射学特征。由于发病率相对较低，有关LCH流行病学的数据有限，每年每百万人口大约有2-5例。LCH有男性倾向，10-20％的病例涉及颌骨，只有1％的病例影响上颌骨，伪装成牙周或根尖周病理学。我们报告了一例48岁女性LCH累及后上颌骨。这是一个与年龄相对应的独特表现，性别,位置和严重性。牙科临床医生应该意识到这一点，并将其视为与未解决的牙周病理学有关的鉴别诊断的一部分，因为它可以在临床和影像学上进行模仿。
