UNASSIGNED: The aim of this study was to evaluate and compare the cytotoxic and genotoxic effects of cigarette and WTS on buccal mucosa.
UNASSIGNED: The pertinent search was done through the computerized literature on MEDLINE, EMBASE, and PUBMED databases, which included case-control, clinical and observational studies regarding the mutagenic effects of cigarettes and WTS in oral tissues. The retraction of data in this study was undertaken from May 2010 to May 2022. A total of 60 articles from the search data were retrieved. This investigation was registered with the research center of Riyadh Elm University for institution review board approval (IRB) and obtained the IRB number \"FRP/2021/448/733/707 and the systematic review registration number with respect to PROSPERO is 345417.
UNASSIGNED: After the removal of duplicates, 32 were evaluated for the inclusion and exclusion criteria. Out of 32 articles, twenty studies were evaluated for cytogenetic abnormalities in buccal mucosal cells of waterpipe tobacco smokers (WTS) and cigarette smokers, and 12 were excluded. The mean MN levels in the oral tissues of WTS were more (1.94 ± 0.39) than in non-smokers (1.68 ± 0.35).
UNASSIGNED: Therefore, we conclude that the MN count can be employed as a biomarker and preliminary signal for the identification of changes in oral mucosa among smokers, which develop towards cancer formation.
■本研究的目的是评估和比较香烟和WTS对颊粘膜的细胞毒性和遗传毒性作用。
■通过MEDLINE的计算机化文献进行了相关搜索,EMBASE,和公共数据库,其中包括病例控制,关于香烟和WTS在口腔组织中的诱变作用的临床和观察性研究。本研究的数据撤回时间为2010年5月至2022年5月。从搜索数据中总共检索到60篇文章。这项调查已在利雅得榆树大学研究中心注册,以获得机构审查委员会(IRB)的批准,并获得IRB编号\“FRP/2021/448/733/707,有关PROSPERO的系统审查注册号为345417。
■删除副本后,对32人的纳入和排除标准进行了评估。在32篇文章中,二十项研究评估了水烟吸烟者(WTS)和吸烟者口腔粘膜细胞遗传学异常,12人被排除在外。WTS口腔组织中的平均MN水平(1.94±0.39)高于非吸烟者(1.68±0.35)。
■因此,我们得出结论,MN计数可以用作识别吸烟者口腔粘膜变化的生物标志物和初步信号,向癌症形成发展。