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Abstract：
Currently, the study outcomes of anthropometric markers to predict the risk of hypertension are still inconsistent due to the effect of racial disparities. This study aims to investigate the most effective predictors for screening and prediction of hypertension (HTN) in the Chinese middle-aged and more elderly adult population and to predict hypertension using obesity and lipid-related markers in Chinese middle-aged and older people.
The data for the cohort study came from the China Health and Retirement Longitudinal Study (CHARLS), including 4423 middle-aged and elderly people aged 45 years or above. We examined 13 obesity- and lipid-related indices, including waist circumference (WC), body mass index (BMI), waist-height ratio (WHtR), visceral adiposity index (VAI), a body shape index (ABSI), body roundness index (BRI), lipid accumulation product index (LAP), conicity index (CI), Chinese visceral adiposity index (CVAI), triglyceride-glucose index (TyG-index) and their combined indices (TyG-BMI, TyG-WC, TyG-WHtR). To compare the capacity of each measure to forecast the probability of developing HTN, the receiver operating characteristic curve (ROC) was used to determine the usefulness of anthropometric indices for screening for HTN in the elderly and determining their cut-off value, sensitivity, specificity, and area under the curve (AUC). Association analysis of 13 obesity-related anthropometric indicators with HTN was performed using binary logistic regression analysis.
During the four years, the incident rates of HTN in middle-aged and elderly men and women in China were 22.08% and 17.82%, respectively. All the above 13 indicators show a modest predictive power (AUC > 0.5), which is significant for predicting HTN in adults (middle-aged and elderly people) in China (P < 0.05). In addition, when WHtR = 0.501 (with an AUC of 0.593, and sensitivity and specificity of 63.60% and 52.60% respectively) or TYg-WHtR = 4.335 (with an AUC of 0.601, and sensitivity and specificity of 58.20% and 59.30% respectively), the effect of predicting the incidence risk of men is the best. And when WHtR = 0.548 (with an AUC of 0.609, and sensitivity and specificity of 59.50% and 56.50% respectively) or TYg-WHtR = 4.781(with an AUC of 0.617, and sensitivity and specificity of 58.10% and 60.80% respectively), the effect of predicting the incidence risk of women is the best.
The 13 obesity- and lipid-related indices in this study have modest significance for predicting HTN in Chinese middle-aged and elderly patients. WHtR and Tyg-WHtR are the most cost-effective indicators with moderate predictive value of the development of HTN.
The data for the cohort study came from the China Health and Retirement Longitudinal Study (CHARLS), including 4423 middle-aged and elderly people aged 45 years or above. We examined 13 obesity- and lipid-related indices, including waist circumference (WC), body mass index (BMI), waist-height ratio (WHtR), visceral adiposity index (VAI), a body shape index (ABSI), body roundness index (BRI), lipid accumulation product index (LAP), conicity index (CI), Chinese visceral adiposity index (CVAI), triglyceride-glucose index (TyG-index) and their combined indices (TyG-BMI, TyG-WC, TyG-WHtR). To compare the capacity of each measure to forecast the probability of developing HTN, the receiver operating characteristic curve (ROC) was used to determine the usefulness of anthropometric indices for screening for HTN in the elderly and determining their cut-off value, sensitivity, specificity, and area under the curve (AUC). Association analysis of 13 obesity-related anthropometric indicators with HTN was performed using binary logistic regression analysis.
During the four years, the incident rates of HTN in middle-aged and elderly men and women in China were 22.08% and 17.82%, respectively. All the above 13 indicators show a modest predictive power (AUC > 0.5), which is significant for predicting HTN in adults (middle-aged and elderly people) in China (P < 0.05). In addition, when WHtR = 0.501 (with an AUC of 0.593, and sensitivity and specificity of 63.60% and 52.60% respectively) or TYg-WHtR = 4.335 (with an AUC of 0.601, and sensitivity and specificity of 58.20% and 59.30% respectively), the effect of predicting the incidence risk of men is the best. And when WHtR = 0.548 (with an AUC of 0.609, and sensitivity and specificity of 59.50% and 56.50% respectively) or TYg-WHtR = 4.781(with an AUC of 0.617, and sensitivity and specificity of 58.10% and 60.80% respectively), the effect of predicting the incidence risk of women is the best.
The 13 obesity- and lipid-related indices in this study have modest significance for predicting HTN in Chinese middle-aged and elderly patients. WHtR and Tyg-WHtR are the most cost-effective indicators with moderate predictive value of the development of HTN.
摘要：
背景：目前，由于种族差异的影响,人体测量指标预测高血压风险的研究结果仍然不一致.本研究旨在探讨中国中老年人群高血压（HTN）筛查和预测的最有效预测因子，并使用肥胖和血脂相关指标预测中国中老年人群的高血压。
方法：队列研究的数据来自中国健康与退休纵向研究（CHARLS），其中45岁及以上中老年人4423人。我们检查了13项肥胖和脂质相关指标，包括腰围（WC），体重指数（BMI），腰高比（WHtR），内脏肥胖指数（VAI），身体形状指数(ABSI)，身体圆度指数（BRI），脂质积累产物指数（LAP），锥度指数(CI)，中国内脏肥胖指数（CVAI），甘油三酯-葡萄糖指数(TyG-指数)及其组合指数(TyG-BMI，TyG-WC,TyG-WHtR）。为了比较每种措施预测发展HTN的可能性的能力，受试者工作特征曲线（ROC）用于确定人体测量指标在老年人中筛查HTN并确定其临界值的有用性，灵敏度,特异性，和曲线下面积(AUC)。采用二元logistic回归分析对13项肥胖相关人体测量指标与HTN的相关性进行分析。
结果：在四年中，我国中老年男女HTN发生率分别为22.08%和17.82%,分别。上述13项指标均显示出适度的预测能力(AUC>0.5)，对我国成年人(中老年人)HTN的预测具有重要意义(P<0.05)。此外,当WHtR=0.501（AUC为0.593，敏感性和特异性分别为63.60%和52.60%）或TYg-WHtR=4.335（AUC为0.601，敏感性和特异性分别为58.20%和59.30%）时，预测男性发病风险的效果最好。当WHtR=0.548（AUC为0.609，敏感性和特异性分别为59.50％和56.50％）或TYg-WHtR=4.781（AUC为0.617，敏感性和特异性分别为58.10％和60.80％）时，预测女性发病风险的效果最好。
结论：本研究中的13项肥胖和血脂相关指标对预测中国中老年患者的HTN具有中等意义。WHtR和Tyg-WHtR是最具成本效益的指标，对HTN的发展具有中等预测价值。
方法：队列研究的数据来自中国健康与退休纵向研究（CHARLS），其中45岁及以上中老年人4423人。我们检查了13项肥胖和脂质相关指标，包括腰围（WC），体重指数（BMI），腰高比（WHtR），内脏肥胖指数（VAI），身体形状指数(ABSI)，身体圆度指数（BRI），脂质积累产物指数（LAP），锥度指数(CI)，中国内脏肥胖指数（CVAI），甘油三酯-葡萄糖指数(TyG-指数)及其组合指数(TyG-BMI，TyG-WC,TyG-WHtR）。为了比较每种措施预测发展HTN的可能性的能力，受试者工作特征曲线（ROC）用于确定人体测量指标在老年人中筛查HTN并确定其临界值的有用性，灵敏度,特异性，和曲线下面积(AUC)。采用二元logistic回归分析对13项肥胖相关人体测量指标与HTN的相关性进行分析。
结果：在四年中，我国中老年男女HTN发生率分别为22.08%和17.82%,分别。上述13项指标均显示出适度的预测能力(AUC>0.5)，对我国成年人(中老年人)HTN的预测具有重要意义(P<0.05)。此外,当WHtR=0.501（AUC为0.593，敏感性和特异性分别为63.60%和52.60%）或TYg-WHtR=4.335（AUC为0.601，敏感性和特异性分别为58.20%和59.30%）时，预测男性发病风险的效果最好。当WHtR=0.548（AUC为0.609，敏感性和特异性分别为59.50％和56.50％）或TYg-WHtR=4.781（AUC为0.617，敏感性和特异性分别为58.10％和60.80％）时，预测女性发病风险的效果最好。
结论：本研究中的13项肥胖和血脂相关指标对预测中国中老年患者的HTN具有中等意义。WHtR和Tyg-WHtR是最具成本效益的指标，对HTN的发展具有中等预测价值。
