METHODS: The search was conducted using four search engines (PubMed, Scopus, Embase, and Cochrane), using the Boolean operator to combine mesh terms such as PbtO2, CA, and HIBI.
RESULTS: Among 1,077 records, 22 studies were included (16 experimental studies and six clinical studies). In experimental studies, PbtO2 was mainly adopted to assess the impact of gas exchanges, drugs, or systemic maneuvers on brain oxygenation. In human studies, PbtO2 was rarely used to monitor the brain oxygen tension in patients with CA and HIBI. PbtO2 values had no clear association with patients\' outcomes, but in the experimental studies, brain tissue hypoxia was associated with increased inflammation and neuronal damage.
CONCLUSIONS: Further studies are needed to validate the effect and the threshold of PbtO2 associated with outcome in patients with CA, as well as to understand the physiological mechanisms influencing PbtO2 induced by gas exchanges, drug administration, and changes in body positioning after CA.
方法:使用四个搜索引擎进行搜索(PubMed,Scopus,Embase,和Cochrane),使用布尔运算符组合网格项,如PbtO2、CA、和HIBI。
结果:在1,077条记录中,包括22项研究(16项实验研究和6项临床研究)。在实验研究中,PbtO2主要用于评估气体交换的影响,毒品,或对脑氧合的全身性操作。在人类研究中,PbtO2很少用于监测CA和HIBI患者的脑氧张力。PbtO2值与患者预后无明显关联,但在实验研究中,脑组织缺氧与炎症和神经元损伤增加有关。
结论:需要进一步的研究来验证与CA患者预后相关的PbtO2的效果和阈值,以及了解由气体交换引起的影响PbtO2的生理机制,药物管理,以及CA后身体定位的变化。