We conducted 2 online studies with US adults examining television ads for fictional prescription drugs indicated to treat lung cancer (N = 385) or multiple myeloma (N = 406). The ads included claims about OS, ORR with and without a disclosure, or PFS with and without a disclosure. In each experiment, we randomized participants to view 1 of 5 versions of a television ad. After viewing the ad twice, participants completed a questionnaire that measured understanding, perceptions, and other outcomes.
In both studies, participants correctly differentiated between OS, ORR, and PFS via open-ended responses; however, participants in the PFS conditions (versus ORR conditions) were more likely to make incorrect inferences about OS. Supporting the hypothesis, adding a disclosure made expectations around living longer and quality-of-life improvements more accurate.
Disclosures could help reduce the extent to which people misinterpret endpoints like ORR and PFS. More research is needed to establish best-practice recommendations for using disclosures to improve patient understanding of drug efficacy without changing their perception of the drug in unintended ways.
方法:我们对美国成年人进行了2项在线研究,以检查电视广告中虚构的处方药,这些处方药用于治疗肺癌(N=385)或多发性骨髓瘤(N=406)。这些广告包括关于操作系统的声明,ORR有或没有披露,或PFS,有或没有披露。在每个实验中,我们随机分配参与者观看电视广告的5个版本中的1个。看了两次广告后,参与者完成了一份测量理解的问卷,感知,和其他结果。
结果:在两项研究中,参与者正确区分了操作系统,ORR,和PFS通过开放式响应;然而,PFS条件(与ORR条件相比)的参与者更有可能对OS做出不正确的推断.支持这个假设,增加披露使人们对寿命更长和生活质量改善的期望更加准确。
结论:披露有助于降低人们对ORR和PFS等终点的误解程度。需要更多的研究来建立最佳实践建议,以使用披露来提高患者对药物疗效的理解,而不会以意想不到的方式改变他们对药物的看法。