Abstract：
Polycystic ovary syndrome (PCOS) is a common gynecological disease that causes adverse effects in women in their reproductive phase. Nonetheless, the molecular mechanisms remain unclear. Over the last decade, sequencing and omics approaches have advanced at an increased pace. Omics initiatives have come to the forefront of biomedical research by presenting the significance of biological functions and processes. Thus, multi-omics profiling has yielded important insights into understanding the biology of PCOS by identifying potential biomarkers and therapeutic targets. Multi-omics platforms provide high-throughput data to leverage the molecular mechanisms and pathways involving genetic alteration, epigenetic regulation, transcriptional regulation, protein interaction, and metabolic alterations in PCOS. The purpose of this review is to outline the prospects of multi-omics technologies in PCOS research by revealing novel biomarkers and therapeutic targets. Finally, we address the knowledge gaps and emerging treatment strategies for the management of PCOS. Future PCOS research in multi-omics at the single-cell level may enhance diagnostic and treatment options.
摘要：
多囊卵巢综合征（PCOS）是一种常见的妇科疾病，在妇女的生殖阶段会引起不良反应。尽管如此，分子机制尚不清楚。在过去的十年里，测序和组学方法以更快的速度发展。通过提出生物功能和过程的重要性，组学倡议已经成为生物医学研究的前沿。因此，通过识别潜在的生物标志物和治疗靶点,多组学分析对理解PCOS生物学产生了重要的见解.多组学平台提供高通量数据，以利用涉及遗传改变的分子机制和途径，表观遗传调控，转录调控，蛋白质相互作用，和PCOS的代谢改变。这篇综述的目的是通过揭示新的生物标志物和治疗靶标来概述多组学技术在PCOS研究中的前景。最后,我们解决了PCOS管理的知识差距和新兴的治疗策略.未来多囊卵巢综合征在单细胞水平上的研究可能会增强诊断和治疗选择。
