PDF(Pubmed)
Abstract：
While phosphodiesterase type 5 inhibitors (PDE5is) and others are used to treat Erectile dysfunction (ED), many patients are either unresponsive or resistant to it. Stem cell therapy (SCT) is a promising alternative approach. Numerous preclinical trials have demonstrated improved erectile function in animal models using SCT, although the number of clinical trials investigating SCT for men with ED is limited. Nonetheless, findings from human clinical trials suggest that SCT may be a useful treatment option.
Biomedical literature, including PubMed, ClinicalTrials.gov, and European Union Clinical Trials Registry, were analyzed to summarize and synthesize information on stem cell therapy for ED in this narrative review. The achievements in preclinical and clinical evaluations are presented and critically analyzed.
SCT has demonstrated some benefits in improving erectile function, while further studies are urgently needed. Such studies would provide valuable insights into the optimal use of stem cell therapy and its potential as a therapeutic option for ED. Taking advantage of different mechanisms of action involved in various regenerative therapies, combination therapies such as SCT and low-energy shock waves or platelet-rich plasma may provide a more effective therapy and warrant further research.
Biomedical literature, including PubMed, ClinicalTrials.gov, and European Union Clinical Trials Registry, were analyzed to summarize and synthesize information on stem cell therapy for ED in this narrative review. The achievements in preclinical and clinical evaluations are presented and critically analyzed.
SCT has demonstrated some benefits in improving erectile function, while further studies are urgently needed. Such studies would provide valuable insights into the optimal use of stem cell therapy and its potential as a therapeutic option for ED. Taking advantage of different mechanisms of action involved in various regenerative therapies, combination therapies such as SCT and low-energy shock waves or platelet-rich plasma may provide a more effective therapy and warrant further research.
摘要：
■虽然5型磷酸二酯酶抑制剂（PDE5is）和其他用于治疗勃起功能障碍（ED），许多患者要么反应迟钝，要么对它有抵抗力。干细胞治疗（SCT）是一种有前途的替代方法。许多临床前试验表明，在使用SCT的动物模型中，勃起功能得到改善。尽管研究男性ED患者SCT的临床试验数量有限.尽管如此，人体临床试验的结果表明,SCT可能是一种有用的治疗选择.
■生物医学文献，包括PubMed,ClinicalTrials.gov,和欧盟临床试验注册中心，在这篇叙述性综述中，进行了分析，总结和综合了干细胞治疗ED的信息。介绍并严格分析了临床前和临床评估的成就。
■SCT在改善勃起功能方面表现出一些益处，虽然迫切需要进一步的研究。这些研究将为干细胞疗法的最佳使用及其作为ED治疗选择的潜力提供有价值的见解。利用各种再生疗法中涉及的不同作用机制，联合治疗,如SCT和低能量冲击波或富血小板血浆可能提供更有效的治疗,值得进一步研究.
■生物医学文献，包括PubMed,ClinicalTrials.gov,和欧盟临床试验注册中心，在这篇叙述性综述中，进行了分析，总结和综合了干细胞治疗ED的信息。介绍并严格分析了临床前和临床评估的成就。
■SCT在改善勃起功能方面表现出一些益处，虽然迫切需要进一步的研究。这些研究将为干细胞疗法的最佳使用及其作为ED治疗选择的潜力提供有价值的见解。利用各种再生疗法中涉及的不同作用机制，联合治疗,如SCT和低能量冲击波或富血小板血浆可能提供更有效的治疗,值得进一步研究.
