METHODS: From Jan 2021 to Oct 2022, 20 patients with superficial ESCC were enrolled as the ESCC group, while 20 age and gender matched individuals without gastroesophageal reflux disease (GERD) symptoms and 20 age and gender matched patients with GERD symptoms were recruited as the control groups. Patients received 24 h MII-pH and HRM procedure before endoscopic submucosal dissection (ESD), and the data were then collected to identify the type of reflux and esophageal dysmotility.
RESULTS: Prevalence of esophageal dysmotility was significantly different among the three groups, 75.0% in the ESCC group, 35.0% in the non-GERD group and 70.0% in the GERD group (P = 0.029). NAR episodes at 15 cm above the lower esophageal sphincter (LES) in the ESCC group were significantly higher than that in the non-GERD group (6.5 (3.5-9.3) vs 1.0 (0.8-4.0), P = 0.001) and were similar with that in the GERD group (6.5 (3.5-9.3) vs 5.5 (3.0-10.5), P > 0.05). NAR episodes at 5 cm above LES was significantly higher in the ESCC group than that in the non-GERD group (38.0 (27.0-60.0) vs 18.0 (11.8-25.8), P = 0.001) and was significantly higher than that in the GERD group (38.0 (27.0-60.0) vs 20.0 (9.8-30.5)), P = 0.010). Prevalence of pathologic non-acid reflux was significantly different among the three groups, 30.0% in the ESCC group, 0.0% in the non-GERD group and 10.0% in the GERD group (P < 0.001).
CONCLUSIONS: Our study found NAR and esophageal dysfunction frequently occur in ESCC patients. NAR and esophageal dysmotility may be associated with ESCC.
BACKGROUND: ChiCTR2200061456.
方法:从2021年1月至2022年10月,招募了20例浅表性ESCC患者作为ESCC组,纳入20名年龄和性别相匹配的无胃食管反流病(GERD)症状的个体和20名年龄和性别相匹配的有GERD症状的患者作为对照组.患者在内镜黏膜下剥离术(ESD)前接受24hMII-pH和HRM程序,然后收集数据以确定反流和食管动力障碍的类型。
结果:三组间食管动力障碍的患病率有显著差异,ESCC组75.0%,非GERD组35.0%,GERD组70.0%(P=0.029)。ESCC组食管下括约肌(LES)上方15cm处的NAR发作明显高于非GERD组(6.5(3.5-9.3)比1.0(0.8-4.0),P=0.001),与GERD组相似(6.5(3.5-9.3)vs5.5(3.0-10.5),P>0.05)。ESCC组LES以上5cm处的NAR发作明显高于非GERD组(38.0(27.0-60.0)vs18.0(11.8-25.8),P=0.001),并显着高于GERD组(38.0(27.0-60.0)vs20.0(9.8-30.5)),P=0.010)。病理性非酸反流的患病率在三组间有显著差异,ESCC组的30.0%,非GERD组0.0%,GERD组10.0%(P<0.001)。
结论:我们的研究发现,在ESCC患者中经常发生NAR和食管功能障碍。NAR和食管动力障碍可能与ESCC有关。
背景:ChiCTR2200061456。