PDF(Pubmed)
Abstract：
Mitogenomes are essential due to their contribution to cell respiration. Recently they have also been implicated in fungal pathogenicity mechanisms. Members of the basidiomycetous yeast genus Malassezia are an important fungal component of the human skin microbiome, linked to various skin diseases, bloodstream infections, and they are increasingly implicated in gut diseases and certain cancers. In this study, the comparative analysis of Malassezia mitogenomes contributed to phylogenetic tree construction for all species. The mitogenomes presented significant size and gene order diversity which correlates to their phylogeny. Most importantly, they showed the inclusion of large inverted repeats (LIRs) and G-quadruplex (G4) DNA elements, rendering Malassezia mitogenomes a valuable test case for elucidating the evolutionary mechanisms responsible for this genome diversity. Both LIRs and G4s coexist and convergently evolved to provide genome stability through recombination. This mechanism is common in chloroplasts but, hitherto, rarely found in mitogenomes.
摘要：
有丝分裂基因组是必不可少的，因为它们对细胞呼吸有贡献。最近，它们也与真菌致病性机制有关。担子菌酵母属马拉色菌的成员是人类皮肤微生物组的重要真菌成分，与各种皮肤病有关,血流感染,它们越来越多地与肠道疾病和某些癌症有关。在这项研究中,马拉色菌有丝分裂基因组的比较分析有助于所有物种的系统发育树的构建。有丝分裂基因组具有显着的大小和基因顺序多样性，这与它们的系统发育有关。最重要的是,它们显示包含大型反向重复序列（LIR）和G-四链体（G4）DNA元件，使马拉色菌有丝分裂基因组成为阐明负责这种基因组多样性的进化机制的有价值的测试案例。LIR和G4s两者共存并融合进化以通过重组提供基因组稳定性。这种机制在叶绿体中很常见，但是，迄今为止,在有丝分裂基因组中很少发现。
