Abstract：
Chronic rhinosinusitis with nasal polyps (CRSwNP) is a highly prevalent and burdensome disease for both individuals and health systems. Its management involves many specialties, including otorhinolaryngology, allergology, pulmonology, primary care, pharmacy, and pediatrics. A multidisciplinary approach and the participation of the patient in decision-making are essential, both for diagnosis and for therapy. The authors of the consensus aim to translate current knowledge into an easy-to-read practical guide and emphasize those aspects requiring further discussion or with unmet needs owing to the lack of appropriate scientific evidence. An iterative approach for the development of an evidence-based systematic review with recommendations was followed using a standard quality assessment approach (Scottish Intercollegiate Guidelines Network [SIGN] and National Institute for Health and Care Excellence [NICE]). The guideline was critically evaluated using the Appraisal of Guidelines for Research and Evaluation (AGREE II) and Recommendation Excellence (AGREE REX) instruments. Consequently, POLINA has been considered a high-quality guideline by an independent agency. The POLINA consensus provides new definitions of control, therapeutic management (including surgery and evaluation of severity), indications for use of biologics, and response. Finally, this guideline focuses on unmet research needs in CRSwNP.
摘要：
慢性鼻窦炎伴鼻息肉（CRSwNP）对于个人和卫生系统来说是一种高度流行和累赘的疾病，其管理涉及许多专业：耳鼻咽喉科，变态反应学,肺科,初级保健,药房,和儿科.多学科方法和患者参与决策至关重要，用于诊断和治疗策略。共识的作者旨在将当前的知识转化为易于阅读的实用指南，并强调由于缺乏适当的科学证据而仍然存在讨论或未满足需求的方面。使用了一种迭代方法来开发基于证据的系统审查，并提出了建议，使用标准的质量评估方案（苏格兰校际指南网络-SIGN-和国家健康与护理卓越研究所-NIC-），并通过工具评估研究和评估指南（AGREEII）和卓越推荐（AGREEREX）对指南进行了严格评估。根据上述情况,POLINA已被独立机构视为高质量的准则。POLINA共识为控制定义提供了新的方案，治疗管理，包括严重程度评估和手术，以及生物使用和反应的适应症。最后,本指南侧重于CRSwNP中未满足的研究需求。
