PDF(Pubmed)
Abstract：
Chlamydia psittaci (C. psittaci) pneumonia is a zoonotic infectious disease caused by C. psittaci, which is often underdiagnosed. The application of metagenomic next-generation sequencing (mNGS) provides an unbiased method for the detection of unknown pathogens. A 46-year-old man received empirical treatment with piperacillin-tazobactam and moxifloxacin after an initial diagnosis of prostatitis and pneumonia. However, he experienced recurrent symptoms and a cough, and a chest computed tomography (CT) showed aggravated pulmonary inflammation. Upon further questioning, the patient recalled a history of contact with pigeons, and a bronchoscope alveolar lavage fluid analysis with mNGS suggested C. psittaci infection. Following treatment with doxycycline, the patient\'s symptoms were rapidly alleviated, and chest CT showed pulmonary lesions absorption. The patient was followed up for 1 month without any discomfort. This case highlights that initial manifestations of C. psittaci pneumonia may present with atypical symptoms such as prostatitis. Furthermore, mNGS can be a useful tool for the detection of rare or unknown pathogens such as C. psittaci.
摘要：
披肩衣原体（C.Psittaci）肺炎是由C.psittaci引起的人畜共患传染病，这往往是诊断不足。宏基因组下一代测序（mNGS）的应用为检测未知病原体提供了一种无偏的方法。一名46岁的男子在初步诊断出前列腺炎和肺炎后，接受了哌拉西林-他唑巴坦和莫西沙星的经验性治疗。然而,他反复出现症状和咳嗽，胸部计算机断层扫描（CT）显示肺部炎症加重。经进一步询问,病人回忆了与鸽子的接触史,用mNGS进行的支气管镜肺泡灌洗液分析提示鹦鹉感染。用强力霉素治疗后，患者的症状迅速缓解，胸部CT显示肺部病灶吸收。患者随访1个月，无任何不适。该病例突出表明，鹦鹉热杆菌肺炎的最初表现可能伴有不典型症状，如前列腺炎。此外，mNGS可以是用于检测稀有或未知病原体如鹦鹉的有用工具。
