PDF(Pubmed)
Abstract：
Parkinson\'s disease (PD) is a prevalent neurodegenerative disorder that occurs in old age due to a decrease in dopamine, which causes nerve cell destruction. This disease is difficult to diagnose since its symptoms are similar to those of the aging process. Those with PD have impaired motor control and function, dyskinesia, and tremors. To treat PD, drugs that enhance the amount of dopamine given to the brain are administered to alleviate symptoms. This inquiry examines the prescription of rotigotine to achieve this objective. The primary objective of this review is to examine the usage of rotigotine in both the late and early stages of PD. The statistical model utilized in the review found that there was not a significant difference in the dosage of rotigotine prescribed to late and early-stage PD patients, however, there were some confounding variables that may have skewed this result; therefore, further research is necessary to validate or nullify this hypothesis.
摘要：
帕金森病（PD）是一种普遍的神经退行性疾病，由于多巴胺的减少而发生在老年，导致神经细胞破坏.这种疾病很难诊断，因为它的症状与衰老过程的症状相似。患有PD的人的运动控制和功能受损，运动障碍,和颤抖。为了治疗PD，增加给予大脑多巴胺量的药物用于缓解症状。本调查检查了罗替戈汀的处方以实现这一目标。这篇综述的主要目的是研究罗替戈汀在PD晚期和早期的使用。审查中使用的统计模型发现，晚期和早期PD患者的罗替戈汀处方剂量没有显着差异，然而,有一些混杂变量可能扭曲了这一结果；因此，需要进一步的研究来验证或取消这一假设。
