PDF(Pubmed)
Abstract：
Phenytoin is a commonly used anticonvulsant drug for the prophylaxis of generalized tonic-clonic seizures, partial seizures, and neurosurgery-related seizure prevention. Phenytoin-induced thrombocytopenia is a rare but life-threatening condition. Close monitoring of blood counts may be necessary for patients receiving phenytoin, as delay in diagnosis or withdrawal of the drug can be life-threatening. Clinical manifestations of phenytoin-induced thrombocytopenia are usually reported within one to three weeks after drug initiation. In this article, we report a unique case of drug-induced thrombocytopenia that manifested as multiple hemorrhagic lesions in the oral mucous membrane three months after phenytoin initiation.
摘要：
苯妥英是一种常用的抗惊厥药物，用于预防全身性强直阵挛性癫痫发作，部分癫痫发作,和神经外科相关的癫痫发作预防。苯妥英引起的血小板减少症是一种罕见但危及生命的疾病。对于接受苯妥英的患者，可能需要密切监测血细胞计数，因为延迟诊断或停药可能危及生命。苯妥英钠引起的血小板减少症的临床表现通常在药物开始后1至3周内报告。在这篇文章中,我们报道了一例独特的药物性血小板减少症病例,在苯妥英钠治疗3个月后表现为口腔粘膜多发出血性病变.
