Abstract：
Flavonoids are secondary metabolites abundantly present in plants and, in most cases, essential contributors to plants bioactivity. They have been studied so far for a range of possible health-beneficial effects, including antioxidant, cardioprotective, and cytotoxic. Therefore, there are data on the antimicrobial potential of a significant number of flavonoids. However, less is known regarding their antivirulence traits. Trending antimicrobial research worldwide has pointed out the promising effects of antimicrobial strategies based on the antivirulence principle, so this review aims to present the newest research regarding the antivirulence effects of flavonoids. Articles on antivirulence flavonoids published from 2015 until now were selected. A range of molecules from this class has been studied up to date, with the most abundant data for quercetin and myricetin, while the most studied organism is Pseudomonas aeruginosa. The antivirulence attributes studied included antibiofilm assessment, followed by data on the inhibition of virulence pigments (pyocyanin, violacein, and staphyloxanthin) and virulence enzyme production (such as sortase A and elastase). Less information is collected on the inhibition of morphological transition, motility, and molecular mechanisms underlying the antivirulence properties of flavonoids and in vivo research. Flavonoids are a group of compounds with a wide range of antivirulence traits and might be further developed into essential parts of novel antimicrobial strategies.
摘要：
类黄酮是植物中大量存在的次生代谢产物,在大多数情况下,植物生物活性的重要贡献者。到目前为止，已经对它们进行了一系列可能对健康有益的影响的研究，包括抗氧化剂，心脏保护,和细胞毒性。因此,有大量类黄酮的抗菌潜力的数据。然而,关于它们的抗毒力特性知之甚少。全球趋势的抗菌研究指出了基于抗毒力原理的抗菌策略的有希望的效果，因此，本文旨在介绍有关黄酮类化合物的抗毒作用的最新研究。选择了从2015年到现在发表的关于抗毒力类黄酮的文章。迄今为止，已经研究了这一类的一系列分子，槲皮素和杨梅素的数据最丰富，而研究最多的生物是铜绿假单胞菌。研究的抗毒力属性包括抗生物膜评估，其次是抑制毒力色素的数据(绿脓苷，紫罗兰素,和葡萄黄质）和毒力酶的产生（例如分选酶A和弹性蛋白酶）。收集的关于抑制形态转变的信息较少，运动性,以及黄酮类化合物的抗毒力特性和体内研究的分子机制。黄酮类化合物是一组具有广泛抗毒力特性的化合物，可能进一步发展成为新型抗菌策略的重要组成部分。
