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Abstract：
Nanophotothermal agents that provide efficient and precise treatment at tumor sites are attracting increasing attention in biomedicine. In particular, the method combination of nanophotothermal agents and magnetic resonance imaging (MRI) shows great promise for biomedical therapeutic applications. Herein, a simple nanophotothermal agent with dopamine multivalent-modified polyaspartic acid chelated superparamagnetic iron oxide (SPIO) and ferric ion (SPIO@PAsp-DAFe/PEG) was developed for MRI-guided near-infrared photothermal therapy (PTT). SPIO@PAsp-DAFe/PEG was random SPIO nanocluster with good water solubility, had a diameter of 57.8 ± 7.8 nm in dynamic light scattering, negatively charged surface (zeta potential = -11 mV), exhibited good stability and outstanding photothermal conversion efficiency (35.4%) and produced superior magnetic resonance enhanced imaging. In the experiment with tumor-bearing mice, the MRI not only monitored the accumulation of SPIO@PAsp-DAFe/PEG nanocomposites enhanced by near-infrared irradiation after intravenous administration but also determined the appropriate time window for PTT. With the use of MRI-guided near-infrared therapy, the SPIO@PAsp-DAFe/PEG nanocomposites provided excellent therapeutic effects, confirming their great potential as effective MRI/PTT therapeutic agents.
摘要：
在肿瘤部位提供有效和精确治疗的纳米光热剂在生物医学中引起了越来越多的关注。特别是,纳米光热剂和磁共振成像（MRI）的方法组合显示了生物医学治疗应用的巨大前景。在这里，开发了一种简单的纳米光热剂，该纳米光热剂具有多巴胺多价修饰的聚天冬氨酸螯合的超顺磁性氧化铁（SPIO）和三价铁离子（SPIO@PAsp-DAFe/PEG），用于MRI引导的近红外光热治疗（PTT）。SPIO@PAsp-DAFe/PEG是具有良好水溶性的随机SPIO纳米簇,在动态光散射中直径为57.8±7.8nm，带负电荷的表面（ζ电位=-11mV），表现出良好的稳定性和出色的光热转换效率（35.4％），并产生了出色的磁共振增强成像。在荷瘤小鼠的实验中，MRI不仅监测了静脉给药后近红外照射增强的SPIO@PAsp-DAFe/PEG纳米复合材料的积累,还确定了PTT的适当时间窗.使用MRI引导的近红外治疗，SPIO@PAsp-DAFe/PEG纳米复合材料提供了优异的治疗效果，证实其作为有效MRI/PTT治疗剂的巨大潜力。
