PDF(Pubmed)
Abstract：
Chronic obstructive pulmonary disease (COPD) constitutes a set of heterogeneous symptoms affecting millions of people worldwide. The associated comorbidities developing in COPD involve dysregulation in physiological pathways resulting from systemic inflammation in respiratory airways. In addition to mentioning the pathophysiology, stages, and consequences of COPD, this paper also defines red blood cell (RBC) indices such as hemoglobin, hematocrit, mean corpuscular volume, mean corpuscular hemoglobin concentration, red blood cell distribution width, and RBC count. It explains the role of RBC indices and RBC structural abnormalities with disease severity and exacerbations in COPD patients. Although many factors have been studied as a marker of morbidity and mortality for COPD patients, RBC indices have emerged as revolutionary evidence. Therefore, the effectiveness of evaluating RBC indices in COPD patients and their importance as a negative predictor of survival, mortality, and clinical outcomes have been debated through rigorous literature reviews. Furthermore, the prevalence, mechanisms of development, and prognosis of underlying anemia and polycythemia in COPD have also been evaluated, with anemia most significantly associated with COPD. Therefore, more studies should be conducted to address underlying anemia in COPD patients to lessen the severity and disease burden. Correcting the RBC indices in COPD patients remarkably impacts the quality of life and reduces in-patient admissions, healthcare resource utilization, and costs. Hence, it is noteworthy to understand the significance of considering RBC indices while dealing with COPD patients.
摘要：
慢性阻塞性肺疾病(COPD)构成了影响全世界数百万人的一组异质性症状。在COPD中发展的相关合并症涉及由呼吸气道中的全身性炎症引起的生理途径的失调。除了提到病理生理学，阶段,以及COPD的后果，本文还定义了红细胞（RBC）指标，如血红蛋白，血细胞比容,平均红细胞体积，平均红细胞血红蛋白浓度，红细胞分布宽度,和红细胞计数。它解释了RBC指数和RBC结构异常与COPD患者疾病严重程度和恶化的作用。尽管已经研究了许多因素作为COPD患者发病率和死亡率的标志，RBC指数已经成为革命性的证据。因此,评估COPD患者RBC指数的有效性及其作为生存阴性预测因子的重要性，死亡率,通过严格的文献综述对临床结局进行了辩论.此外，患病率,发展机制,并对COPD患者的原发性贫血和红细胞增多症的预后进行了评估，贫血与COPD最显著相关。因此,应开展更多的研究来解决COPD患者的潜在贫血,以减轻患者的严重程度和疾病负担.校正COPD患者的RBC指数显著影响生活质量并减少住院，医疗保健资源利用，和成本。因此，值得注意的是,在治疗COPD患者时考虑RBC指数的意义.
