PDF(Pubmed)
Abstract：
UNASSIGNED: Cognitive dysfunction presents one of the chief causes of postoperative morbidity. Melatonin as a neurohormone can improve neurocognitive functioning and sleep disorders. We evaluated the effect of melatonin on the postoperative cognitive function of patients undergoing coronary artery bypass grafting (CABG).
UNASSIGNED: A triple-blind randomized-controlled trial was conducted on 66 CABG candidates in Namazee Hospital (Shiraz, Iran). Patients were assigned equally into two groups receiving melatonin 10 mg or a placebo daily for 4 weeks before surgery and 2 days after surgery in the intensive care unit. The Mini-Mental State Examination (MMSE), Tower of London (ToL), and Wechsler Adults Intelligence Scale-Revised (WAIS-R) cognitive function tests were performed in both groups 4 weeks before surgery (time point 1), 2 days after surgery (time point 2), and 6 weeks after initial administration of melatonin (time point 3).
UNASSIGNED: The mean change score (time point 3-time point 1) differed significantly between the two groups in the MMSE (P ≤ 0.001), ToL total score (P = 0.001), and WAIS-R general IQ (P ≤ 0.001), picture completion (P ≤ 0.001), vocabulary (P = 0.024), and digit span (P = 0.01). On the other hand, no significant differences were detected in the WAIS-R block design, ToL total time delay, ToL total lab, and ToL total result scores.
UNASSIGNED: The MMSE and WAIS-R tests revealed that melatonin might have prophylactic effects against postoperative cognitive disturbance in patients undergoing elective CABG.
UNASSIGNED: A triple-blind randomized-controlled trial was conducted on 66 CABG candidates in Namazee Hospital (Shiraz, Iran). Patients were assigned equally into two groups receiving melatonin 10 mg or a placebo daily for 4 weeks before surgery and 2 days after surgery in the intensive care unit. The Mini-Mental State Examination (MMSE), Tower of London (ToL), and Wechsler Adults Intelligence Scale-Revised (WAIS-R) cognitive function tests were performed in both groups 4 weeks before surgery (time point 1), 2 days after surgery (time point 2), and 6 weeks after initial administration of melatonin (time point 3).
UNASSIGNED: The mean change score (time point 3-time point 1) differed significantly between the two groups in the MMSE (P ≤ 0.001), ToL total score (P = 0.001), and WAIS-R general IQ (P ≤ 0.001), picture completion (P ≤ 0.001), vocabulary (P = 0.024), and digit span (P = 0.01). On the other hand, no significant differences were detected in the WAIS-R block design, ToL total time delay, ToL total lab, and ToL total result scores.
UNASSIGNED: The MMSE and WAIS-R tests revealed that melatonin might have prophylactic effects against postoperative cognitive disturbance in patients undergoing elective CABG.
摘要：
■认知功能障碍是术后发病的主要原因之一。褪黑素作为一种神经激素可以改善神经认知功能和睡眠障碍。我们评估了褪黑素对冠状动脉旁路移植术（CABG）患者术后认知功能的影响。
■在Namazee医院对66名CABG候选人进行了一项三盲随机对照试验（设拉子，伊朗)。在手术前和手术后2天，患者被平均分为两组，每天接受10mg褪黑激素或安慰剂，持续4周。迷你精神状态检查（MMSE），伦敦塔(ToL),和韦克斯勒成人智力量表修订（WAIS-R）认知功能测试在手术前4周（时间点1），手术后2天（时间点2），和初始施用褪黑激素后6周(时间点3)。
■在MMSE中，两组之间的平均变化评分（时间点3-时间点1）显着不同（P≤0.001），TOL总分（P=0.001），和WAIS-R一般智商(P≤0.001)，图片完成（P≤0.001），词汇量（P=0.024），和数字跨度(P=0.01)。另一方面,在WAIS-R块设计中没有检测到显著差异，ToL总时间延迟,总实验室，和ToL总分。
■MMSE和WAIS-R测试表明，褪黑素可能对择期CABG患者的术后认知障碍具有预防作用。
■在Namazee医院对66名CABG候选人进行了一项三盲随机对照试验（设拉子，伊朗)。在手术前和手术后2天，患者被平均分为两组，每天接受10mg褪黑激素或安慰剂，持续4周。迷你精神状态检查（MMSE），伦敦塔(ToL),和韦克斯勒成人智力量表修订（WAIS-R）认知功能测试在手术前4周（时间点1），手术后2天（时间点2），和初始施用褪黑激素后6周(时间点3)。
■在MMSE中，两组之间的平均变化评分（时间点3-时间点1）显着不同（P≤0.001），TOL总分（P=0.001），和WAIS-R一般智商(P≤0.001)，图片完成（P≤0.001），词汇量（P=0.024），和数字跨度(P=0.01)。另一方面,在WAIS-R块设计中没有检测到显著差异，ToL总时间延迟,总实验室，和ToL总分。
■MMSE和WAIS-R测试表明，褪黑素可能对择期CABG患者的术后认知障碍具有预防作用。
