UNASSIGNED: A triple-blind randomized-controlled trial was conducted on 66 CABG candidates in Namazee Hospital (Shiraz, Iran). Patients were assigned equally into two groups receiving melatonin 10 mg or a placebo daily for 4 weeks before surgery and 2 days after surgery in the intensive care unit. The Mini-Mental State Examination (MMSE), Tower of London (ToL), and Wechsler Adults Intelligence Scale-Revised (WAIS-R) cognitive function tests were performed in both groups 4 weeks before surgery (time point 1), 2 days after surgery (time point 2), and 6 weeks after initial administration of melatonin (time point 3).
UNASSIGNED: The mean change score (time point 3-time point 1) differed significantly between the two groups in the MMSE (P ≤ 0.001), ToL total score (P = 0.001), and WAIS-R general IQ (P ≤ 0.001), picture completion (P ≤ 0.001), vocabulary (P = 0.024), and digit span (P = 0.01). On the other hand, no significant differences were detected in the WAIS-R block design, ToL total time delay, ToL total lab, and ToL total result scores.
UNASSIGNED: The MMSE and WAIS-R tests revealed that melatonin might have prophylactic effects against postoperative cognitive disturbance in patients undergoing elective CABG.
■在Namazee医院对66名CABG候选人进行了一项三盲随机对照试验(设拉子,伊朗)。在手术前和手术后2天,患者被平均分为两组,每天接受10mg褪黑激素或安慰剂,持续4周。迷你精神状态检查(MMSE),伦敦塔(ToL),和韦克斯勒成人智力量表修订(WAIS-R)认知功能测试在手术前4周(时间点1),手术后2天(时间点2),和初始施用褪黑激素后6周(时间点3)。
■在MMSE中,两组之间的平均变化评分(时间点3-时间点1)显着不同(P≤0.001),TOL总分(P=0.001),和WAIS-R一般智商(P≤0.001),图片完成(P≤0.001),词汇量(P=0.024),和数字跨度(P=0.01)。另一方面,在WAIS-R块设计中没有检测到显著差异,ToL总时间延迟,总实验室,和ToL总分。
■MMSE和WAIS-R测试表明,褪黑素可能对择期CABG患者的术后认知障碍具有预防作用。