PDF(Pubmed)
Abstract：
Lithium has been used as a treatment for bipolar disorder for over half a century, but there has thus far been no clinical differentiation made between the two naturally occurring stable isotopes (6Li and 7Li). While the natural lithium salts commonly used in treatments are composed of a mixture of these two stable isotopes (approximately 7.59% 6Li and 92.41% 7Li), some preliminary research indicates the above two stable isotopes of lithium may have differential effects on rat behaviour and neurophysiology. Here, we evaluate whether lithium isotopes may have distinct effects on HT22 neuronal cell viability, GSK-3-β phosphorylation in HT22 cells, and GSK-3-β kinase activity. We report no significant difference in lithium isotope toxicity on HT22 cells, nor in GSK-3-β phosphorylation, nor in GSK-3-β kinase activity between the two isotopes of lithium.
摘要：
半个多世纪以来，锂一直被用作双相情感障碍的治疗方法，但是到目前为止，两种天然存在的稳定同位素（6Li和7Li）之间还没有临床区别。虽然治疗中常用的天然锂盐由这两种稳定同位素（约7.59%6Li和92.41%7Li）的混合物组成，一些初步研究表明，上述两种稳定的锂同位素可能对大鼠行为和神经生理学有不同的影响。这里,我们评估锂同位素是否对HT22神经元细胞活力有明显影响，HT22细胞中的GSK-3-β磷酸化,和GSK-3-β激酶活性。我们报道锂同位素对HT22细胞的毒性没有显着差异，在GSK-3-β磷酸化中也没有，锂的两个同位素之间的GSK-3-β激酶活性也没有。
