Abstract：
Intravesical bacillus Calmette-Guérin (BCG) is a common and highly effective treatment for non-muscle invasive urothelial carcinoma of the urinary bladder. BCG may cause an autoimmune reaction in some patients. One hundred and fifty-eight papers were analyzed, for a total of hundred and thirty patients with reactive arthritis, sixty patients with ocular manifestations and eighteen patients with other rheumatologic diseases. Among 130 subjects with reactive arthritis, an autoimmune symptom occurred after 5 instillations of intravesical BCG (IQR 4-6), which represents 5 weeks in most cases. Fifty-one patients had concurrent ocular involvement. The resolution of symptoms was achieved in a median of 32.5 days (IQR 14-90). Forty-two men and twenty women had ocular manifestations, most commonly conjunctivitis. Patients with HLA-B27 typing had earlier presentation of ocular symptoms related to the number of instillations (4.5 vs 6 [p < 0.05]. Resolution of symptoms was achieved at a median of 128 days (IQR 21-150). Among patients treated with NSAIDs (either with or without steroids), the duration of the disease was significantly shorter in both the articular and the ocular groups (28 vs. 120 [p < 0.05] and 30 vs.105 [p < 0.05], respectively). Other autoimmune manifestations included general autoimmune diseases, such as vasculitis, psoriasis and myasthenia gravis.
摘要：
膀胱内芽孢杆菌卡介苗（BCG）是一种常见且高效的非肌肉浸润性膀胱尿路上皮癌治疗方法。BCG可能在某些患者中引起自身免疫反应。分析了一百五十八篇论文，总共一百三十名反应性关节炎患者，60例眼部表现患者和18例其他风湿病患者。在130名反应性关节炎患者中，在5次膀胱内滴注BCG（IQR4-6）后出现自身免疫症状，在大多数情况下代表5周。51例患者并发眼部受累。症状的缓解在32.5天的中位数（IQR14-90）内实现。42名男性和20名女性有眼部表现，最常见的是结膜炎。HLA-B27分型患者较早出现与滴注次数相关的眼部症状（4.5vs6[p<0.05]。在128天的中位数(IQR21-150)达到症状的消退。在接受NSAIDs治疗的患者（含或不含类固醇）中，关节组和眼部组的疾病持续时间明显缩短(28vs.120[p<0.05]和30vs.105[p<0.05]，分别)。其他自身免疫表现包括一般的自身免疫性疾病，比如血管炎,牛皮癣和重症肌无力。
