PDF(Pubmed)
Abstract：
Development of the outflow tract of the heart requires specification, proliferation and deployment of a progenitor cell population from the second heart field to generate the myocardium at the arterial pole of the heart. Disruption of these processes leads to lethal defects in rotation and septation of the outflow tract. We previously showed that Fibroblast Growth Factor 8 (FGF8) directs a signaling cascade in the second heart field that regulates critical aspects of OFT morphogenesis. Here we show that in addition to the survival and proliferation cues previously described, FGF8 provides instructive and patterning information to OFT myocardial cells and their progenitors that prevents their aberrant differentiation along a working myocardial program.
摘要：
心脏流出道的发展需要规范，从第二心脏区域增殖和部署祖细胞群，以在心脏的动脉极处产生心肌。这些过程的中断导致流出道的旋转和分隔的致命缺陷。我们先前表明成纤维细胞生长因子8(FGF8)在调节OFT形态发生的关键方面的第二心脏场中引导信号级联。在这里，我们表明，除了先前描述的存活和增殖线索，FGF8为OFT心肌细胞及其祖细胞提供指导性和图案化信息，以防止其沿着工作心肌程序的异常分化。
