PDF(Pubmed)
Abstract：
Electronic cigarettes are often used for smoking cessation as a harm reduction strategy, but studies comparing risks of electronic cigarettes (ECs) and tobacco cigarettes (TCs) are scarce. Ventricular repolarization in people who smoke TCs is abnormal. Baseline repolarization was compared among nonusers (people who do not use TCs or ECs) and people who use ECs or TCs. The acute effects of ECs and TCs on metrics of ventricular repolarization were then compared in people who chronically smoke. A total of 110 participants (59 female), including 35 people (21 females) in the TC cohort, 34 people (17 females) in the EC cohort, and 41 people (21 females) in the nonuser cohort, were included. None of the primary outcomes, Tpeak-end (Tp-e), Tp-e/QT, and Tp-e/QTc, were different among the three cohorts at supine baseline, even when adjusted for sex. When compared with the control exposure standing after acutely using the EC but not the TC, significantly prolonged all three primary indices of ventricular repolarization in people who smoke TCs. The major new finding in this study is that in people who smoke TCs, using an EC compared with a TC significantly prolongs ventricular repolarization. Furthermore, in our subgroup analysis by sex, this adverse effect on repolarization is found only in male, not female, smokers. In summary, chronic TC smoking is the most prevalent, modifiable risk factor for cardiovascular death, including sudden cardiac death. If used for smoking cessation, ECs should only be used in the short term since they too carry their own risks; this risk appears to be greatest in males compared with females who smoke.NEW & NOTEWORTHY The major new finding in this study is that in people who smoke tobacco cigarettes, using an electronic cigarette but not a tobacco cigarette acutely and significantly prolongs several metrics of ventricular repolarization, including Tpeak-Tend, Tpeak-Tend/QT, and Tpeak-Tend/QTc. Furthermore, in our subgroup analysis by sex, this adverse effect on repolarization is found only in male, not female, smokers.
摘要：
电子烟通常用于戒烟，作为减少危害的策略。但是比较电子烟（EC）和烟草烟（TC）风险的研究很少。吸烟TC的人的心室复极化异常。比较了非吸烟者的基线复极化，以及使用EC或TC的人。然后，ECs和TC对心室复极指标的急性影响，在长期吸烟的人群中进行了比较。共有110名参与者（59名女性），包括TC队列中的35人（21名女性），EC队列中的34人（17名女性），非吸烟者（NS）队列中包括41人（21名女性）。没有一个主要结果，Tp-e,Tp-e/QT,和Tp-e/QTc，在基线时三个队列中不同，即使适应了性别。与对照曝光相比，在剧烈使用EC后站立，但TC并未显着延长吸烟者心室复极的所有三个主要指标。这项研究的主要新发现是，在吸烟的人中，与TC相比，使用EC可显着延长心室复极。Further,在我们按性别分组的分析中，这种对复极化的不利影响仅在男性中发现，不是女性吸烟者。总之,慢性TC吸烟是最普遍的，心血管死亡的可变危险因素，包括心脏性猝死.如果用于戒烟，ECs只能在短期内使用，因为它们也有自己的风险；与吸烟的女性相比，男性的风险似乎最大。
