Abstract：
Mucin 6 (MUC6) is a secreted gel-forming mucin covering the surfaces of gastrointestinal and other tissues. Published work demonstrates that MUC6 can also be expressed in several cancer types and can aid in the distinction of different tumor entities. To systematically analyze MUC6 expression in normal and cancerous tissues, a tissue microarray containing 15 412 samples from 119 different tumor types and subtypes as well as 608 samples of 76 different normal tissue types was analyzed by immunohistochemistry. At least a weak MUC6 positivity was seen in 50 of 119 (42%) tumor entities. Thirty-three tumor entities included tumors with strong positivity. MUC6 immunostaining was most frequent in mucinous carcinomas of the breast (44%), adenocarcinomas of the stomach (30%-40%) and esophagus (35%), and neuroendocrine carcinomas of the colon. Strong MUC6 staining was linked to advanced pT stage (p = 0.0464), defective mismatch repair status and right-sided tumor location (p < 0.0001 each) in colorectal cancer, as well as to high tumor grade (p = 0.0291), nodal metastasis (p = 0.0485), erb-b2 receptor tyrosine kinase 2 positivity (p < 0.0001) and negative estrogen receptor (p = 0.0332)/progesterone receptor (p = 0.0257) status in breast carcinomas of no special type. The broad range of tumor types with MUC6 expression limits the utility of MUC6 immunohistochemistry for the distinction of different tumor types.
摘要：
粘蛋白6（MUC6）是一种分泌的凝胶形成粘蛋白，覆盖胃肠道和其他组织的表面。已发表的工作证明MUC6也可以在几种癌症类型中表达并且可以帮助区分不同的肿瘤实体。为了系统分析MUC6在正常组织和癌组织中的表达，通过免疫组织化学分析了组织微阵列,其中包含来自119种不同肿瘤类型和亚型的15412个样本以及来自76种不同正常组织类型的608个样本.在119个(42%)肿瘤实体中的50个中观察到至少弱MUC6阳性。33个肿瘤实体包括具有强阳性的肿瘤。MUC6免疫染色在乳腺粘液性癌中最常见（44％），胃（30％-40％）和食管（35％）的腺癌，和结肠神经内分泌癌。强MUC6染色与pT分期进展相关(p=0.0464),结肠直肠癌中缺陷性错配修复状态和右侧肿瘤位置（每个p<0.0001），以及高肿瘤等级（p=0.0291），淋巴结转移（p=0.0485），在无特殊类型的乳腺癌中，erb-b2受体酪氨酸激酶2阳性（p<0.0001）和阴性雌激素受体（p=0.0332）/孕激素受体（p=0.0257）状态。具有MUC6表达的广泛的肿瘤类型限制了MUC6免疫组织化学用于区分不同肿瘤类型的用途。
