PDF(Pubmed)
Abstract：
UNASSIGNED: Neutrophil gelatin lipase carrier protein (NGAL) has been used as an early biomarker to predict acute kidney injury (AKI). However, the predictive value of NGAL in urine and blood in children with acute kidney injury in different backgrounds remains unclear. Therefore, we conducted this systematic review and meta-analysis to explore the clinical value of NGAL in predicting AKI in children.
UNASSIGNED: Computerized databases were searched for relevant the studies published through August 4th, 2022, which included PUBMED, EMBASE, COCHRANE and Web of science. The risk of bias of the original included studies was assessed by using the Quality Assessment of Studies for Diagnostic Accuracy (QUADA-2). At the same time, subgroup analysis of these data was carried out.
UNASSIGNED: Fifty-three studies were included in this meta-analysis, involving 5,049 patients, 1,861 of whom were AKI patients. The sensitivity and specificity of blood NGAL for predicting AKI were 0.79 (95% CI: 0.69-0.86) and 0.85 (95% CI: 0.75-0.91), respectively, and SROC was 0.89 (95% CI: 0.86-0.91). The sensitivity and specificity of urine NGAL for predicting AKI were 0.83 (95% CI: 0.78-0.87) and 0.81 (95% CI: 0.77-0.85), respectively, and SROC was 0.89 (95% CI: 0.86-0.91). Meanwhile, the sensitivity and specificity of overall NGAL (urine and blood NGAL) for predicting AKI in children were 0.82 (95% CI: 0.77-0.86) and 0.82 (95% CI: 0.78-0.86), respectively, and SROC was 0.89 (95% CI: 0.86-0.91).
UNASSIGNED: NGAL is a valuable predictor for AKI in children under different backgrounds. There is no significant difference in the prediction accuracy between urine NGAL and blood NGAL, and there is also no significant difference in different measurement methods of NGAL. Hence, NGAL is a non-invasive option in clinical practice. Based on the current evidence, the accuracy of NGAL measurement is the best at 2 h after cardiopulmonary bypass (CPB) and 24 h after birth in asphyxiated newborns.
UNASSIGNED: https://www.crd.york.ac.uk/prospero/, identifier: CRD42022360157.
UNASSIGNED: Computerized databases were searched for relevant the studies published through August 4th, 2022, which included PUBMED, EMBASE, COCHRANE and Web of science. The risk of bias of the original included studies was assessed by using the Quality Assessment of Studies for Diagnostic Accuracy (QUADA-2). At the same time, subgroup analysis of these data was carried out.
UNASSIGNED: Fifty-three studies were included in this meta-analysis, involving 5,049 patients, 1,861 of whom were AKI patients. The sensitivity and specificity of blood NGAL for predicting AKI were 0.79 (95% CI: 0.69-0.86) and 0.85 (95% CI: 0.75-0.91), respectively, and SROC was 0.89 (95% CI: 0.86-0.91). The sensitivity and specificity of urine NGAL for predicting AKI were 0.83 (95% CI: 0.78-0.87) and 0.81 (95% CI: 0.77-0.85), respectively, and SROC was 0.89 (95% CI: 0.86-0.91). Meanwhile, the sensitivity and specificity of overall NGAL (urine and blood NGAL) for predicting AKI in children were 0.82 (95% CI: 0.77-0.86) and 0.82 (95% CI: 0.78-0.86), respectively, and SROC was 0.89 (95% CI: 0.86-0.91).
UNASSIGNED: NGAL is a valuable predictor for AKI in children under different backgrounds. There is no significant difference in the prediction accuracy between urine NGAL and blood NGAL, and there is also no significant difference in different measurement methods of NGAL. Hence, NGAL is a non-invasive option in clinical practice. Based on the current evidence, the accuracy of NGAL measurement is the best at 2 h after cardiopulmonary bypass (CPB) and 24 h after birth in asphyxiated newborns.
UNASSIGNED: https://www.crd.york.ac.uk/prospero/, identifier: CRD42022360157.
摘要：
■中性粒细胞明胶脂肪酶载体蛋白（NGAL）已被用作预测急性肾损伤（AKI）的早期生物标志物。然而,尿液和血液中NGAL对不同背景急性肾损伤患儿的预测价值尚不清楚.因此,我们进行了系统评价和荟萃分析,以探讨NGAL在预测儿童AKI中的临床价值.
■搜索了计算机化数据库，以查找截至8月4日发表的相关研究，2022年，其中包括PUBMED，EMBASE,COCHRANE和WebofScience。通过使用诊断准确性研究质量评估（QUADA-2）评估原始纳入研究的偏倚风险。同时,对这些数据进行亚组分析.
■本荟萃分析包括53项研究，涉及5049名患者,其中1861人为AKI患者。血NGAL预测AKI的敏感性和特异性分别为0.79(95%CI:0.69-0.86)和0.85(95%CI:0.75-0.91),分别,SROC为0.89（95%CI：0.86-0.91）。尿NGAL预测AKI的敏感性和特异性分别为0.83(95%CI:0.78-0.87)和0.81(95%CI:0.77-0.85),分别,SROC为0.89（95%CI：0.86-0.91）。同时,总体NGAL（尿液和血液NGAL）预测儿童AKI的敏感性和特异性分别为0.82（95％CI：0.77-0.86）和0.82（95％CI：0.78-0.86），分别,SROC为0.89（95%CI：0.86-0.91）。
■NGAL是不同背景下儿童AKI的有价值的预测指标。尿液NGAL和血液NGAL的预测准确性没有显着差异。不同的NGAL测量方法也没有显著差异。因此，NGAL是临床实践中的非侵入性选择。根据目前的证据,窒息新生儿在体外循环（CPB）后2小时和出生后24小时NGAL测量的准确性最好。
■https://www.crd.约克。AC.英国/普华永道/，标识符：CRD42022360157。
■搜索了计算机化数据库，以查找截至8月4日发表的相关研究，2022年，其中包括PUBMED，EMBASE,COCHRANE和WebofScience。通过使用诊断准确性研究质量评估（QUADA-2）评估原始纳入研究的偏倚风险。同时,对这些数据进行亚组分析.
■本荟萃分析包括53项研究，涉及5049名患者,其中1861人为AKI患者。血NGAL预测AKI的敏感性和特异性分别为0.79(95%CI:0.69-0.86)和0.85(95%CI:0.75-0.91),分别,SROC为0.89（95%CI：0.86-0.91）。尿NGAL预测AKI的敏感性和特异性分别为0.83(95%CI:0.78-0.87)和0.81(95%CI:0.77-0.85),分别,SROC为0.89（95%CI：0.86-0.91）。同时,总体NGAL（尿液和血液NGAL）预测儿童AKI的敏感性和特异性分别为0.82（95％CI：0.77-0.86）和0.82（95％CI：0.78-0.86），分别,SROC为0.89（95%CI：0.86-0.91）。
■NGAL是不同背景下儿童AKI的有价值的预测指标。尿液NGAL和血液NGAL的预测准确性没有显着差异。不同的NGAL测量方法也没有显著差异。因此，NGAL是临床实践中的非侵入性选择。根据目前的证据,窒息新生儿在体外循环（CPB）后2小时和出生后24小时NGAL测量的准确性最好。
■https://www.crd.约克。AC.英国/普华永道/，标识符：CRD42022360157。
