Abstract：
Cerebral excitability and systemic metabolic balance are closely interconnected. Energy supply to neurons depends critically on glucose, whose fluctuations can promote immediate hyperexcitability resulting in acute symptomatic seizures. On the other hand, chronic disorders of sugar metabolism (e.g., diabetes mellitus) are often associated with long-term epilepsy. In this paper, we aim to review the existing knowledge on the association between acute and chronic glycaemic imbalances (hyper- and hypoglycaemia) with seizures and epilepsy, especially in the developing brain, focusing on clinical and instrumental features in order to optimize the care of children and adolescents and prevent the development of chronic neurological conditions in young patients.
摘要：
大脑兴奋性和全身代谢平衡密切相关。神经元的能量供应主要取决于葡萄糖，其波动可促进立即过度兴奋，导致急性症状性癫痫发作。另一方面,慢性糖代谢紊乱(例如，糖尿病）通常与长期癫痫有关。在本文中,我们的目的是回顾关于急性和慢性血糖失衡（高血糖和低血糖）与癫痫发作和癫痫之间的关联的现有知识，尤其是在发育中的大脑中，专注于临床和仪器特征，以优化儿童和青少年的护理，并防止年轻患者慢性神经系统疾病的发展。
