PDF(Pubmed)
Abstract：
Although diagnosis and treatment of vestibular schwannomas (VSs) improved in recent years, no factors have yet been identified as being capable of predicting tumor growth. Molecular rearrangements occur in neoplasms before any macroscopic morphological changes become visible, and the former are the underlying cause of disease behavior. Tumor microenvironment (TME) encompasses cellular and non-cellular elements interacting together, resulting in a complex and dynamic key of tumorigenesis, drug response, and treatment outcome. The aim of this systematic, narrative review was to assess the level of knowledge on TME implicated in the biology, behavior, and prognosis of sporadic VSs. A search (updated to November 2022) was run in Scopus, PubMed, and Web of Science electronic databases according to the PRISMA guidelines, retrieving 624 titles. After full-text evaluation and application of inclusion/exclusion criteria, 37 articles were included. VS microenvironment is determined by the interplay of a dynamic ecosystem of stromal and immune cells which produce and remodel extracellular matrix, vascular networks, and promote tumor growth. However, evidence is still conflicting. Further studies will enhance our understanding of VS biology by investigating TME-related biomarkers able to predict tumor growth and recognize immunological and molecular factors that could be potential therapeutic targets for medical treatment.
摘要：
尽管近年来前庭神经鞘瘤(VSs)的诊断和治疗有所改善,目前还没有发现能够预测肿瘤生长的因素.肿瘤分子重排发生在任何宏观形态变化变得可见之前，前者是疾病行为的根本原因。肿瘤微环境（TME）包括细胞和非细胞元件相互作用在一起，导致肿瘤发生的复杂而动态的关键，药物反应,和治疗结果。这个系统的目的，叙事回顾是评估生物学中涉及的TME知识水平，行为，散发性VSs的预后。在Scopus进行了搜索（更新至2022年11月），PubMed,根据PRISMA指南和WebofScience电子数据库，检索624个标题。在全文评估和应用纳入/排除标准后，共包括37篇文章。VS微环境是由产生和重塑细胞外基质的基质和免疫细胞的动态生态系统的相互作用决定的。血管网络，促进肿瘤生长。然而,证据仍然相互矛盾。进一步的研究将通过研究能够预测肿瘤生长并识别可能是医学治疗的潜在治疗靶标的TME相关生物标志物来增强我们对VS生物学的理解。
