PDF(Pubmed)
Abstract：
: Chronic cigarette smoking is a major risk factor for many serious diseases. While complete cessation of smoking is the best option to reduce harm from smoking, adverse impacts of smoking on health could persist for several years after cessation. Therefore, Biomarkers of Potential Harm (BoPH) are useful in interim evaluations of the beneficial effects of smoking cessation or switching to potentially lower-risk tobacco products. A 14-day smoking abstinence study was conducted under clinical confinement conditions and enrolled 70 subjects into younger (24-34 years, n = 33) and older (35-60 years, n = 37) age cohorts. Biomarkers of Exposure (BoE), which indicate exposure to nicotine and other toxicants, were measured at baseline, 7 and 14 days. Several BoPH including previously identified eicosanoids (leukotriene 4 (LTE4) and 2,3-dinor thromboxane 2 (2,3-d-TXB2) and others were evaluated. Significant declines in BoE, LTE4, 2,3-d-TXB2, neutrophils, WBC and select RBC, and arterial blood gas parameters were observed in both age cohorts at Days 7 and 14 compared to baseline, while other BoPH (e.g., FeNO) showed age-related effects. Rapid and reproducible reductions in LTE4, 2,3-d-TXB2 WBC, and neutrophil counts were consistently detected following smoking abstinence, indicating the value of these markers as useful BoPH.
摘要：
：长期吸烟是许多严重疾病的主要危险因素。虽然完全戒烟是减少吸烟危害的最佳选择，戒烟后吸烟对健康的不利影响可能持续数年.因此,潜在危害生物标志物（BoPH）可用于戒烟或转向潜在风险较低的烟草产品的有益影响的中期评估。在临床禁闭条件下进行了为期14天的禁烟研究，并招募了70名年轻受试者（24-34岁，n=33）及以上（35-60岁，n=37）年龄组。暴露生物标志物（BoE），这表明暴露于尼古丁和其他有毒物质，在基线测量，7和14天评估了几种BoPH，包括先前鉴定的类二十烷酸（白三烯4（LTE4）和2,3-二或血栓烷2（2,3-d-TXB2）等。英国央行大幅下跌，LTE4,2,3-d-TXB2,中性粒细胞,WBC并选择RBC，与基线相比，在第7天和第14天观察到两个年龄组的动脉血气参数，而其他BOPH(例如，FeNO）显示出与年龄有关的影响。LTE4，2,3-d-TXB2WBC的快速和可重复减少，和中性粒细胞计数在戒烟后被一致检测到，表明这些标记的值是有用的BoPH。
