METHODS: Sixteen adult ADPKD patients were enrolled in the study. Eleven patients (68.8%) were male, and the median age was 42 years (IQR 36-47.5). HRV parameters were calculated using 24 h-ECG Holter. A kidney magnetic resonance imaging (MRI) scan 3 Tesla was performed to evaluate total kidney volume (TKV) and total fibrotic volume (TFV).
RESULTS: A statistically significant positive linear correlation was observed between length of kidneys and frequency domain parameters as low frequency (LF) (r = 0.595, p < 0.05) and LFday (r = 0.587, p < 0.05). Moreover, a statistically significant positive linear correlation exists between high frequency (HF) and TFV (r = 0.804, p < 0.01) or height-adjusted (ha) TFV (r = 0.801, p < 0.01). Finally, we found a statistically significant positive linear correlation between HFnight and TKV (r = 0.608, p < 0.05), ha-TKV (r = 0.685, p < 0.01), TFV (r = 0.594, p < 0.05), and ha-TFV (r = 0.615, p < 0.05).
CONCLUSIONS: We suppose that the increase in TKV and TFV could lead to a parasympathetic tone hyperactivation, probably in response to hypoxic stress and vasoconstriction due to cystic enlargement.
方法:16例成人ADPKD患者纳入研究。11例(68.8%)为男性,中位年龄为42岁(IQR36-47.5).使用24h-ECGHolter计算HRV参数。进行3特斯拉的肾脏磁共振成像(MRI)扫描以评估总肾脏体积(TKV)和总纤维化体积(TFV)。
结果:在肾脏长度与低频(LF)(r=0.595,p<0.05)和LFday(r=0.587,p<0.05)的频域参数之间观察到具有统计学意义的正线性相关。此外,高频(HF)与TFV(r=0.804,p<0.01)或高度调整(ha)TFV(r=0.801,p<0.01)之间存在统计学上的正线性相关。最后,我们发现HFnight和TKV之间存在统计学上显著的正线性相关(r=0.608,p<0.05),ha-TKV(r=0.685,p<0.01),TFV(r=0.594,p<0.05),和ha-TFV(r=0.615,p<0.05)。
结论:我们假设TKV和TFV的增加可能导致副交感神经张力过度激活,可能是对由于囊性肿大引起的低氧压力和血管收缩的反应。