PDF(Pubmed)
Abstract：
Mitophagy is an important mechanism for mitochondrial quality control by regulating autophagosome-specific phagocytosis, degradation and clearance of damaged mitochondria, and involved in cell damage and diseases. Inflammasomes are important inflammation-related factors newly discovered in recent years, which are involved in cell innate immunity and inflammatory response, and play an important role in kidney diseases. Based on the current studies, we reviewed the progress of mitophagy, inflammasomes and their interaction in kidney diseases.
摘要：
线粒体自噬是通过调节自噬体特异性吞噬来控制线粒体质量的重要机制,受损线粒体的降解和清除，并参与细胞损伤和疾病。炎性小体是近年来新发现的重要的炎症相关因子,参与细胞先天免疫和炎症反应，并在肾脏疾病中发挥重要作用。根据目前的研究,我们回顾了线粒体自噬的进展，炎症体及其在肾脏疾病中的相互作用。
