PDF(Pubmed)
Abstract：
Multidrug resistant (MDR) pathogens have become a major global health challenge and have severely threatened the health of society. Current conditions have become worse as a result of the COVID-19 pandemic, and infection rates in the future will rise. It is necessary to design, respond effectively, and take action to address these challenges by investigating new avenues. In this regard, the fabrication of metal NPs utilized by various methods, including green synthesis using mushroom, is highly versatile, cost-effective, eco-compatible, and superior. In contrast, biofabrication of metal NPs can be employed as a powerful weapon against MDR pathogens and have immense biomedical applications. In addition, the advancement in nanotechnology has made possible to modify the nanomaterials and enhance their activities. Metal NPs with biomolecules composite prevent the microbial adhesion and kills the microbial pathogens through biofilm formation. Bacteriocin is an excellent antimicrobial peptide that works well as an augmentation substance to boost the antimicrobial effects. As a result, we concentrate on the creation of new, eco-compatible mycosynthesized metal NPs with bacteriocin nanocomposite via electrostatic, covalent, or non-covalent bindings. The synergistic benefits of metal NPs with bacteriocin to combat MDR pathogens and COVID-19, as well as other biomedical applications, are discussed in this review. Moreover, the importance of the adverse outcome pathway (AOP) in risk analysis of manufactured metal nanocomposite nanomaterial and their future possibilities were also discussed.
摘要：
多药耐药（MDR）病原体已成为全球重大的健康挑战，并严重威胁着社会的健康。由于COVID-19大流行，目前的情况变得更糟，未来感染率将会上升。有必要设计，有效应对,并采取行动，通过调查新的途径来应对这些挑战。在这方面,用各种方法制造金属NP，包括使用蘑菇的绿色合成，是高度通用的，成本效益高,生态兼容，和优越。相比之下,金属纳米粒子的生物制造可以用作对抗MDR病原体的强大武器，并具有巨大的生物医学应用。此外,纳米技术的进步使改性纳米材料和增强其活性成为可能。具有生物分子复合物的金属NP防止微生物粘附并通过生物膜形成杀死微生物病原体。细菌素是一种出色的抗菌肽，可作为增强物质增强抗菌作用。因此,我们专注于创造新的，通过静电与细菌素纳米复合材料的生态相容性金属纳米粒子，共价,或非共价结合。金属纳米粒子与细菌素对抗MDR病原体和COVID-19以及其他生物医学应用的协同优势，在这篇综述中进行了讨论。此外，还讨论了不良结局途径(AOP)在制造的金属纳米复合纳米材料风险分析中的重要性及其未来的可能性.
