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Abstract：
The study aims to determine whether body mass index (BMI), metabolic syndrome (MS) or its individual components (primary hypertension, type 2 diabetes mellitus and dyslipidemias) are risk factors for common urological diseases.
Cross-sectional study with data collected on February 28, 2022 from the TriNetX Research Network. Patients were divided in cohorts according to their BMI, presence of MS (BMI > 30 kg/m2, type 2 diabetes mellitus, primary hypertension and disorders of lipoprotein metabolism) and its individual components and its association with common urological conditions was determined. For each analysis, odds ratio (OR) with 95% confidence intervals were calculated. Statistical significance was assessed at p < .05.
BMI > 30 kg/m2 was associated with increased risk of lithiasis, kidney cancer, overactive bladder, male hypogonadism, benign prostatic hyperplasia, and erectile dysfunction (p < .05). On the contrary, BMI was inversely associated with ureteral, bladder and prostate cancer (p < .05). In all urological diseases, MS was the strongest risk factor, with prostate cancer (OR = 2.53) showing the weakest and male hypogonadism the strongest (OR = 13.00) associations.
MS and its individual components were significant risk factors for common urological conditions. Hence holistic approaches with lifestyle modification might prevent common urological disease.Key messagesOverall, metabolic syndrome is the strongest risk factor for all the analysed urological diseases.Abnormally high body mass index can be a risk or protective factor depending on the threshold and urological disease that are being evaluated.Metabolic syndrome and increased BMI should be considered important factors associated to the prevalence of common urological diseases.
Cross-sectional study with data collected on February 28, 2022 from the TriNetX Research Network. Patients were divided in cohorts according to their BMI, presence of MS (BMI > 30 kg/m2, type 2 diabetes mellitus, primary hypertension and disorders of lipoprotein metabolism) and its individual components and its association with common urological conditions was determined. For each analysis, odds ratio (OR) with 95% confidence intervals were calculated. Statistical significance was assessed at p < .05.
BMI > 30 kg/m2 was associated with increased risk of lithiasis, kidney cancer, overactive bladder, male hypogonadism, benign prostatic hyperplasia, and erectile dysfunction (p < .05). On the contrary, BMI was inversely associated with ureteral, bladder and prostate cancer (p < .05). In all urological diseases, MS was the strongest risk factor, with prostate cancer (OR = 2.53) showing the weakest and male hypogonadism the strongest (OR = 13.00) associations.
MS and its individual components were significant risk factors for common urological conditions. Hence holistic approaches with lifestyle modification might prevent common urological disease.Key messagesOverall, metabolic syndrome is the strongest risk factor for all the analysed urological diseases.Abnormally high body mass index can be a risk or protective factor depending on the threshold and urological disease that are being evaluated.Metabolic syndrome and increased BMI should be considered important factors associated to the prevalence of common urological diseases.
摘要：
■该研究旨在确定体重指数（BMI）代谢综合征(MS)或其个体成分(原发性高血压，2型糖尿病和血脂异常）是常见泌尿系统疾病的危险因素。
■具有2022年2月28日从TriNetX研究网络收集的数据的横截面研究。患者根据他们的BMI分为队列，存在MS（BMI>30kg/m2，2型糖尿病，确定了原发性高血压和脂蛋白代谢紊乱）及其各个成分及其与常见泌尿系统疾病的关联。对于每个分析，计算比值比(OR)和95%置信区间.在p<0.05时评估统计学显著性。
■BMI>30kg/m2与结石风险增加有关，肾癌,膀胱过度活动症,男性性腺功能减退,良性前列腺增生,和勃起功能障碍（p<0.05）。相反,BMI与输尿管呈负相关，膀胱癌和前列腺癌（p<0.05）。在所有泌尿系统疾病中，MS是最强的危险因素,前列腺癌（OR=2.53）表现出最弱的性腺功能减退症和男性最强（OR=13.00）的相关性。
■MS及其各个组成部分是常见泌尿系统疾病的重要危险因素。因此，改变生活方式的整体方法可能会预防常见的泌尿系统疾病。关键信息总体上，代谢综合征是所有分析的泌尿系统疾病的最强危险因素。根据正在评估的阈值和泌尿系统疾病，异常高的体重指数可能是风险或保护因素。代谢综合征和BMI增加应被视为与常见泌尿系统疾病患病率相关的重要因素。
■具有2022年2月28日从TriNetX研究网络收集的数据的横截面研究。患者根据他们的BMI分为队列，存在MS（BMI>30kg/m2，2型糖尿病，确定了原发性高血压和脂蛋白代谢紊乱）及其各个成分及其与常见泌尿系统疾病的关联。对于每个分析，计算比值比(OR)和95%置信区间.在p<0.05时评估统计学显著性。
■BMI>30kg/m2与结石风险增加有关，肾癌,膀胱过度活动症,男性性腺功能减退,良性前列腺增生,和勃起功能障碍（p<0.05）。相反,BMI与输尿管呈负相关，膀胱癌和前列腺癌（p<0.05）。在所有泌尿系统疾病中，MS是最强的危险因素,前列腺癌（OR=2.53）表现出最弱的性腺功能减退症和男性最强（OR=13.00）的相关性。
■MS及其各个组成部分是常见泌尿系统疾病的重要危险因素。因此，改变生活方式的整体方法可能会预防常见的泌尿系统疾病。关键信息总体上，代谢综合征是所有分析的泌尿系统疾病的最强危险因素。根据正在评估的阈值和泌尿系统疾病，异常高的体重指数可能是风险或保护因素。代谢综合征和BMI增加应被视为与常见泌尿系统疾病患病率相关的重要因素。
