PDF(Pubmed)
Abstract：
UNASSIGNED: Primary Trigeminal Neuralgia (PTN) is a common and refractory neurological disease. Conventional vascular compression theory could not completely explain the etiology and pathogenesis of PTN. This study used diffusion tensor imaging (DTI) to demonstrate the microstructural changes of root entry zone (REZ) region in PTN patients.
UNASSIGNED: DTI sequences was performed on PTN patients and healthy controls (HCs). Clinical data included affected side, disease course and visual analogue scale (VAS) were collected. Quantitative DTI variables such as FA, MD, AD and RD of the root entry/Exit zone (REZ) were measured and compared in PTN/HCs, affected/unaffected side, and pre/post operation groups. The PCoA was established to conduct overall differences between PTN group and the HCs.
UNASSIGNED: A total of 17 patients with PTN (mean age 59.29 ± 8.53; 5 men) and 34 HCs (mean age 57.70 ± 6.37; 10 men) were included. Lower FA value of the affected side of PTN group was observed compared to the unaffected side and the HCs (p = 0.001), whereas the values of MD, AD and RD were significantly increased (p < 0.001). Moreover, the decrease of FA value was recovered post operation. PCoA results of the comprehensive indexes can significantly distinguish PTN group from HCs (r = 0.500, p < 0.001).
UNASSIGNED: Quantitative variables derived from DTI in REZ had significantly different profiles between PTN patients and HCs, which were associated with VAS situation and the disease course of PTN. The comprehensive index established on DTI variables were of great potential to reveal the microstructure changes in PTN patients and predict the therapeutic effect.
UNASSIGNED: DTI sequences was performed on PTN patients and healthy controls (HCs). Clinical data included affected side, disease course and visual analogue scale (VAS) were collected. Quantitative DTI variables such as FA, MD, AD and RD of the root entry/Exit zone (REZ) were measured and compared in PTN/HCs, affected/unaffected side, and pre/post operation groups. The PCoA was established to conduct overall differences between PTN group and the HCs.
UNASSIGNED: A total of 17 patients with PTN (mean age 59.29 ± 8.53; 5 men) and 34 HCs (mean age 57.70 ± 6.37; 10 men) were included. Lower FA value of the affected side of PTN group was observed compared to the unaffected side and the HCs (p = 0.001), whereas the values of MD, AD and RD were significantly increased (p < 0.001). Moreover, the decrease of FA value was recovered post operation. PCoA results of the comprehensive indexes can significantly distinguish PTN group from HCs (r = 0.500, p < 0.001).
UNASSIGNED: Quantitative variables derived from DTI in REZ had significantly different profiles between PTN patients and HCs, which were associated with VAS situation and the disease course of PTN. The comprehensive index established on DTI variables were of great potential to reveal the microstructure changes in PTN patients and predict the therapeutic effect.
摘要：
■原发性三叉神经痛（PTN）是一种常见且难治性的神经系统疾病。传统的血管压缩理论不能完全解释PTN的病因和发病机制。本研究使用扩散张量成像（DTI）来显示PTN患者根进入区（REZ）区域的微观结构变化。
■对PTN患者和健康对照(HC)进行DTI序列。临床数据包括患侧，收集病程和视觉模拟评分（VAS）。定量DTI变量，如FA，MD,在PTN/HC中测量并比较根入口/出口区（REZ）的AD和RD，受影响/未受影响的一侧，和前/后操作组。建立PCoA以进行PTN组和HC之间的总体差异。
■共纳入17例PTN患者（平均年龄59.29±8.53；5例男性）和34例HCs（平均年龄57.70±6.37；10例男性）。与未受影响的一侧和HC相比，PTN组的受影响一侧的FA值较低（p=0.001），而MD的值，AD和RD显著增高(p<0.001)。此外，术后FA值的下降得到恢复。综合指标的PCoA结果可以显着区分PTN组和HCs（r=0.500，p<0.001）。
■从REZ中的DTI得出的定量变量在PTN患者和HCs之间具有显着不同的特征，与PTN的VAS情况和病程有关。基于DTI变量建立的综合指数在揭示PTN患者的微观结构变化和预测治疗效果方面具有巨大潜力。
■对PTN患者和健康对照(HC)进行DTI序列。临床数据包括患侧，收集病程和视觉模拟评分（VAS）。定量DTI变量，如FA，MD,在PTN/HC中测量并比较根入口/出口区（REZ）的AD和RD，受影响/未受影响的一侧，和前/后操作组。建立PCoA以进行PTN组和HC之间的总体差异。
■共纳入17例PTN患者（平均年龄59.29±8.53；5例男性）和34例HCs（平均年龄57.70±6.37；10例男性）。与未受影响的一侧和HC相比，PTN组的受影响一侧的FA值较低（p=0.001），而MD的值，AD和RD显著增高(p<0.001)。此外，术后FA值的下降得到恢复。综合指标的PCoA结果可以显着区分PTN组和HCs（r=0.500，p<0.001）。
■从REZ中的DTI得出的定量变量在PTN患者和HCs之间具有显着不同的特征，与PTN的VAS情况和病程有关。基于DTI变量建立的综合指数在揭示PTN患者的微观结构变化和预测治疗效果方面具有巨大潜力。
