PDF(Pubmed)
Abstract：
Autophagy is a catabolic self-degradative pathway that promotes the degradation and recycling of intracellular material through the lysosomal compartment. Although first believed to function in conditions of nutritional stress, autophagy is emerging as a critical cellular pathway, involved in a variety of physiological and pathophysiological processes. Autophagy dysregulation is associated with an increasing number of diseases, including ocular diseases. On one hand, mutations in autophagy-related genes have been linked to cataracts, glaucoma, and corneal dystrophy; on the other hand, alterations in autophagy and lysosomal pathways are a common finding in essentially all diseases of the eye. Moreover, LC3-associated phagocytosis, a form of non-canonical autophagy, is critical in promoting visual cycle function. This review collects the latest understanding of autophagy in the context of the eye. We will review and discuss the respective roles of autophagy in the physiology and/or pathophysiology of each of the ocular tissues, its diurnal/circadian variation, as well as its involvement in diseases of the eye.
摘要：
自噬是促进细胞内物质通过溶酶体区室降解和再循环的分解代谢自我降解途径。尽管最初被认为在营养压力的条件下起作用，自噬正在成为一个关键的细胞通路，参与多种生理和病理生理过程。自噬失调与越来越多的疾病有关，包括眼部疾病。一方面,自噬相关基因的突变与白内障有关，青光眼,和角膜营养不良；另一方面，自噬和溶酶体途径的改变是基本上所有眼部疾病中的共同发现。此外，LC3相关吞噬作用,一种非规范的自噬，对促进视觉循环功能至关重要。这篇综述收集了在眼睛背景下对自噬的最新认识。我们将回顾和讨论自噬在每个眼组织的生理和/或病理生理学中的各自作用，其昼夜/昼夜节律变化，以及它与眼部疾病的关系。
