UNASSIGNED: This study evaluated serum IGF-1 in IHH men and controls. Furthermore, we evaluated the association between serum total oestradiol (TE2) and IGF-1 levels in patients and controls. Parameters including age, body mass index and fertility history were analysed.
UNASSIGNED: This prospective study was conducted at the Royan institute.
UNASSIGNED: In 20 men with IHH and 20 controls, serum IGF-1 levels were estimated using chemiluminescence immunoassay and serum E2 levels were assessed by means of the electrochemiluminescence method.
UNASSIGNED: Kolmogorov-Smirnov test, parametric t-test or the Mann-Whitney and the Pearson correlation coefficient were performed. SPSS version 22 was used for the analysis of data.
UNASSIGNED: There was a significant decrease in serum IGF-1 levels in IHH patients compared with controls (145.1 ± 8.9 ng/ml vs. 229.6 ± 7.3 ng/ml P < 0.001, respectively). Furthermore, a significant decrease was observed in TE2 levels in IHH male patients (12.3 ± 2.5 pg/ml) compared with controls (31.9 ± 5.3 pg/ml P < 0.001). A positive correlation was observed between serum IGF-1 and TE2 levels in the total number of participants, suggesting that E2 deficiency in IHH cases can explain the lower levels of serum IGF-1.
UNASSIGNED: These findings suggest that the reduction in IGF-1 levels may be associated with the influence of E2 on the GH/IGF-1 axis, and may confirm the role of the GH/IGF-1 axis in IHH. Further investigations will be required to determine the exact mechanisms by which E2 and IGF-1 affect the reproductive neuroendocrine function.
■本研究评估了IHH男性和对照组的血清IGF-1。此外,我们评估了患者和对照组血清总雌二醇(TE2)和IGF-1水平之间的相关性.参数包括年龄,分析了体重指数和生育史。
■这项前瞻性研究是在Royan研究所进行的。
■在20名患有IHH和20名对照的男性中,使用化学发光免疫分析法评估血清IGF-1水平,并通过电化学发光法评估血清E2水平。
■Kolmogorov-Smirnov试验,进行参数t检验或Mann-Whitney和Pearson相关系数。使用SPSS版本22进行数据分析。
■与对照组相比,IHH患者的血清IGF-1水平显着降低(145.1±8.9ng/mlvs.分别为229.6±7.3ng/ml,P<0.001)。此外,与对照组(31.9±5.3pg/ml,P<0.001)相比,IHH男性患者的TE2水平显著下降(12.3±2.5pg/ml).在参与者总数中,血清IGF-1和TE2水平呈正相关。提示IHH病例中E2缺乏可以解释血清IGF-1水平较低。
■这些发现表明,IGF-1水平的降低可能与E2对GH/IGF-1轴的影响有关,并可能证实GH/IGF-1轴在IHH中的作用。需要进一步的研究来确定E2和IGF-1影响生殖神经内分泌功能的确切机制。