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Abstract：
Krukenberg tumours are unusual metastatic tumours of the ovary with primary tumours from the stomach, breast and gastrointestinal malignancies. Krukenberg tumour from pulmonary malignancy represents an extremely rare situation. This is an elaboration of a case of young women with Krukenberg tumour rising from lung adenocarcinoma. A 38-year-old woman presented with progressive abdominal distention for the past 2-years. Computed tomography (CT) of thorax, abdomen and pelvis revealed a huge ovarian mass with left lung nodules and left-sided pleural effusion. A detailed immunohistochemical staining on pleural fluid cytology confirmed the diagnosis of metastatic adenocarcinoma of lung origin. She underwent doublet platinum chemotherapy as molecular testing for oncogenic mutation was negative. The patient responded well to chemotherapy with a significant reduction in ovarian tumour size. Early identification of the primary source of Krukenberg tumour is paramount to avoid invasive diagnostic surgical intervention for ovarian metastasis.
摘要：
Krukenberg肿瘤是不寻常的卵巢转移性肿瘤，原发性肿瘤来自胃，乳腺和胃肠道恶性肿瘤。来自肺部恶性肿瘤的Krukenberg肿瘤代表了一种极为罕见的情况。这是对一例年轻女性从肺腺癌引起的Krukenberg肿瘤的阐述。在过去的2年中，一名38岁的女性出现了进行性腹胀。胸部计算机断层扫描(CT),腹部和骨盆显示巨大的卵巢肿块，左肺结节和左侧胸腔积液。胸膜液细胞学的详细免疫组织化学染色证实了肺起源的转移性腺癌的诊断。由于癌基因突变的分子检测为阴性，她接受了双铂化疗。患者对化疗反应良好，卵巢肿瘤大小显着减小。早期识别Krukenberg肿瘤的主要来源对于避免卵巢转移的侵入性诊断性手术干预至关重要。
