Abstract：
The odontogenic keratocyst (OKC) is a common cystic lesion of the maxilla and mandible. Squamous cell carcinoma (SCC) arising from OKC or dysplasia occurring in OKC is rare. This study aimed to explore the incidence and clinical features of the dysplasia and malignant transformation of OKC. In this study, 544 patients diagnosed with OKC were collected. Among them, 3 patients were diagnosed as SCC arising from OKC, and 12 patients were diagnosed as OKC with dysplasia. The incidence was calculated. Clinical features were analyzed by chi-square test. In addition, a representative case reconstructing mandible with vascularized fibula flap under general anesthesia was reported. And cases reported before were reviewed. The incidence of the dysplasia and malignant transformation of OKC, which are highly associated with the clinical features of swelling and chronic inflammation, is about 2.76%. But the relevance between the dysplasia and malignant transformation and age, gender together with pain is not statistically high. All in all, the clinical features of swelling and chronic inflammation can be considered as characteristics of the dysplasia and malignant transformation of OKC. Although the pain isn\'t statistically relevant, it may be a dangerous clew. Also, combined with earlier literatures, the dysplasia and malignant transformation of OKC shows unique features of radiographs and histopathology.
摘要：
牙源性角化囊肿（OKC）是上颌骨和下颌骨的常见囊性病变。由OKC或OKC中发生的异型增生引起的鳞状细胞癌（SCC）很少见。本研究旨在探讨OKC异型增生和恶变的发生率及临床特点。在这项研究中,收集544例诊断为OKC的患者。其中,3例患者被诊断为由OKC引起的SCC，12例患者诊断为OKC伴发育不良。计算发生率。采用卡方检验分析临床特征。此外,本文报道1例全麻下应用血管化腓骨皮瓣重建下颌骨。并对以前报告的病例进行了回顾。OKC的异型增生和恶变的发生率，这与肿胀和慢性炎症的临床特征高度相关，约为2.76%。但是发育不良和恶性转化与年龄之间的相关性，性别与疼痛在统计学上并不高。总而言之，肿胀和慢性炎症的临床特征可以认为是OKC的异型增生和恶变的特征。虽然疼痛没有统计学意义,这可能是一个危险的提示。此外，结合早期文献，OKC的异型增生和恶变表现出独特的X线片和组织病理学特征。
