PDF(Pubmed)
Abstract：
This randomized, controlled, blinded study evaluates the efficacy of intense pulsed light (IPL) therapy with low-level light therapy (LLLT) in the treatment of meibomian gland dysfunction (MGD) and evaporative dry eye (EDE) compared to a control group.
Hundred patients with MGD and EDE were randomized into control (50 subjects, 100 eyes) and study group (50 subjects, 100 eyes). The study group underwent three sittings of IPL with LLLT 15 days apart and were followed up 1 month and 2 months after the last treatment sitting. The control group underwent sham treatment and was followed up at the same intervals. The patients were evaluated at baseline and 1 month and 3 months (post 1st treatment) for dry eye. Schirmer\'s test and tear breakup time (TBUT), OSDI, meibomian gland expression, and meibography.
The study group showed significant improvement in OSDI scores (P < 0.0001) compared to the control group and a significant improvement in TBUT (P < 0.005) compared to the control group. There was no change in schirmer\'s test and an improvement in the meibomian gland expression but not significant.
The results show that a combined therapy of IPL with LLT is effective in treating MGD with EDE compared to controls, and repeated treatment sessions have a cumulative effect on the disease outcomes.
Hundred patients with MGD and EDE were randomized into control (50 subjects, 100 eyes) and study group (50 subjects, 100 eyes). The study group underwent three sittings of IPL with LLLT 15 days apart and were followed up 1 month and 2 months after the last treatment sitting. The control group underwent sham treatment and was followed up at the same intervals. The patients were evaluated at baseline and 1 month and 3 months (post 1st treatment) for dry eye. Schirmer\'s test and tear breakup time (TBUT), OSDI, meibomian gland expression, and meibography.
The study group showed significant improvement in OSDI scores (P < 0.0001) compared to the control group and a significant improvement in TBUT (P < 0.005) compared to the control group. There was no change in schirmer\'s test and an improvement in the meibomian gland expression but not significant.
The results show that a combined therapy of IPL with LLT is effective in treating MGD with EDE compared to controls, and repeated treatment sessions have a cumulative effect on the disease outcomes.
摘要：
■这是随机的，控制,与对照组相比,盲法研究评估了强脉冲光(IPL)联合低水平光疗(LLLT)治疗睑板腺功能障碍(MGD)和蒸发性干眼(EDE)的疗效.
■将100名MGD和EDE患者随机分为对照组（50名受试者，100只眼）和研究组（50名受试者，100只眼睛)。研究组间隔15天进行了3次IPL和LLLT，并在最后一次治疗后1个月和2个月进行了随访。对照组进行假治疗，并以相同的间隔进行随访。在基线和1个月和3个月(第一次治疗后)评估患者的干眼。Schirmer'stestandtearbreakuptime(TBUT),OSDI,睑板腺表达，和介体图。
■研究组与对照组相比，OSDI评分显着改善（P<0.0001），与对照组相比，TBUT显着改善（P<0.005）。Schirmer试验无变化，睑板腺表达无改善，但无显著性差异。
■结果表明，与对照组相比，IPL与LLT的联合疗法在用EDE治疗MGD方面是有效的，重复治疗对疾病结局有累积影响。
■将100名MGD和EDE患者随机分为对照组（50名受试者，100只眼）和研究组（50名受试者，100只眼睛)。研究组间隔15天进行了3次IPL和LLLT，并在最后一次治疗后1个月和2个月进行了随访。对照组进行假治疗，并以相同的间隔进行随访。在基线和1个月和3个月(第一次治疗后)评估患者的干眼。Schirmer'stestandtearbreakuptime(TBUT),OSDI,睑板腺表达，和介体图。
■研究组与对照组相比，OSDI评分显着改善（P<0.0001），与对照组相比，TBUT显着改善（P<0.005）。Schirmer试验无变化，睑板腺表达无改善，但无显著性差异。
■结果表明，与对照组相比，IPL与LLT的联合疗法在用EDE治疗MGD方面是有效的，重复治疗对疾病结局有累积影响。
