PDF(Pubmed)
Abstract：
The objective of the study was to compare the efficacy and safety of two concentration of autologous serum (AS) 20% vs 50% in recalcitrant moderate-to-severe dry eye patients.
A double-blind prospective, interventional, and randomized study was done on 44 patients (80 eyes) clinically diagnosed with moderate-to-severe dry eye disease (DED) that was refractory to conventional treatment, and all patients were treated with AS20% or AS50% for 12 weeks. We documented Ocular Surface Disease Index (OSDI), tear film breakup time (TBUT), OXFORD corneal staining score (OSS), and Schirmer test (ST) at baseline, 2,4,8, and 12 weeks. These parameters were compared in both groups and between the groups by using Student\'s t-test. The study included 11 males and 33 females.
Out of 80 eyes, 33 eyes had moderate and 47 had severe DED. The age of patients in AS20% was 44.73 ± 14.37 years, and in AS50% was 46.41 ± 14.47 years. The most common etiology associated with DED was secondary Sjogren syndrome. In moderate DED, both the groups showed significant improvement in both subjective and objective parameters. But in severe DED, the AS20% group failed to show any significant improvement objectively, though subjective improvement was present.
In refractory severe DED patients, AS50% is better option for treatment and in moderate DED both concentrations of autologous serum are effective.
A double-blind prospective, interventional, and randomized study was done on 44 patients (80 eyes) clinically diagnosed with moderate-to-severe dry eye disease (DED) that was refractory to conventional treatment, and all patients were treated with AS20% or AS50% for 12 weeks. We documented Ocular Surface Disease Index (OSDI), tear film breakup time (TBUT), OXFORD corneal staining score (OSS), and Schirmer test (ST) at baseline, 2,4,8, and 12 weeks. These parameters were compared in both groups and between the groups by using Student\'s t-test. The study included 11 males and 33 females.
Out of 80 eyes, 33 eyes had moderate and 47 had severe DED. The age of patients in AS20% was 44.73 ± 14.37 years, and in AS50% was 46.41 ± 14.47 years. The most common etiology associated with DED was secondary Sjogren syndrome. In moderate DED, both the groups showed significant improvement in both subjective and objective parameters. But in severe DED, the AS20% group failed to show any significant improvement objectively, though subjective improvement was present.
In refractory severe DED patients, AS50% is better option for treatment and in moderate DED both concentrations of autologous serum are effective.
摘要：
■该研究的目的是比较两种浓度的自体血清（AS）20％和50％在顽固性中度至重度干眼患者中的疗效和安全性。
■双盲预期，介入,对临床诊断为中度至重度干眼症（DED）的44例患者（80只眼）进行了随机研究，这些患者对常规治疗无效，所有患者均接受AS20%或AS50%治疗12周。我们记录了眼表疾病指数（OSDI），泪膜破裂时间（TBUT），OXFORD角膜染色评分（OSS），和基线时的Schirmer检验（ST），2、4、8和12周。通过使用Studentt检验比较两组和组间的这些参数。该研究包括11名男性和33名女性。
■在80只眼睛中，33只眼中度，47只眼重度DED。AS20%患者年龄为44.73±14.37岁,AS50%为46.41±14.47岁。与DED相关的最常见病因是继发性干燥综合征。在中度DED中，两组的主观和客观参数均有显著改善.但是在严重的DED中，AS20%组客观上没有表现出任何显著的改善，虽然存在主观改善。
■在难治性重症DED患者中，AS50％是更好的治疗选择，在中度DED中，两种浓度的自体血清均有效。
■双盲预期，介入,对临床诊断为中度至重度干眼症（DED）的44例患者（80只眼）进行了随机研究，这些患者对常规治疗无效，所有患者均接受AS20%或AS50%治疗12周。我们记录了眼表疾病指数（OSDI），泪膜破裂时间（TBUT），OXFORD角膜染色评分（OSS），和基线时的Schirmer检验（ST），2、4、8和12周。通过使用Studentt检验比较两组和组间的这些参数。该研究包括11名男性和33名女性。
■在80只眼睛中，33只眼中度，47只眼重度DED。AS20%患者年龄为44.73±14.37岁,AS50%为46.41±14.47岁。与DED相关的最常见病因是继发性干燥综合征。在中度DED中，两组的主观和客观参数均有显著改善.但是在严重的DED中，AS20%组客观上没有表现出任何显著的改善，虽然存在主观改善。
■在难治性重症DED患者中，AS50％是更好的治疗选择，在中度DED中，两种浓度的自体血清均有效。
