PDF(Pubmed)
Abstract：
Dry eye disease is known to have a lot of variability in presentation with overlapping subtypes. Understanding the pathology of this condition will guide therapeutic options. In vivo confocal microscopy is a diagnostic and imaging modality that provides high magnification and high-resolution images of all layers of the cornea and ocular surface. Various structures in the cornea and their alterations due to dry eye have been imaged. The impact of the tear film instability, inflammation, and altered homeostasis on the corneal epithelium, nerves, keratocytes, and dendritic cells have been evaluated across different studies. In addition, key features of IVCM in patients with neuropathic pain have been highlighted in this paper.
摘要：
已知干眼症在重叠亚型的表现上具有很大的变异性。了解这种情况的病理学将指导治疗选择。体内共聚焦显微镜是一种诊断和成像模式，可提供角膜和眼表面所有层的高倍率和高分辨率图像。已经对角膜中的各种结构及其由于干眼引起的改变进行了成像。泪膜不稳定性的影响，炎症,改变了角膜上皮的稳态，神经,角膜细胞,和树突状细胞已经在不同的研究中进行了评估。此外,本文强调了神经性疼痛患者IVCM的主要特征。
