Abstract：
OBJECTIVE: A horizontal corneal diameter greater than 2 standard deviations from the mean (9.8 mm) or greater than 11 mm in term infants defines megalocornea (herein referred to as a large clear cornea). The aim of the current study was to report on the incidence and clinical characteristics of children presenting with large clear cornea that do not suffer glaucoma.
METHODS: A retrospective chart review of children presenting with large clear cornea to the pediatric ophthalmology unit of the ophthalmology department of Alexandria Main University Hospital in the period from March 2011 to December 2020 was conducted. A large clear cornea was defined as a horizontal white-to-white corneal diameter (as measured by calipers) greater than 12 mm. Glaucoma was diagnosed according to the childhood glaucoma research network (CGRN) criteria and the axial length was used to filter out eyes with large clear corneas due to congenital high myopia.
RESULTS: Out of 120 eyes of 91 (58 males) children a total of 76 eyes of 67 (41 males) children were diagnosed with glaucoma and 44 eyes of 24 (17 males) children (36.7%) did not suffer glaucoma. Out of these, 30 eyes were classified as myopia and 14 eyes as congenital megalocornea.
CONCLUSIONS: More than one third of eyes presenting with large clear corneas may not have glaucoma, and almost two thirds of these eyes (that are not suffering from glaucoma) demonstrate axial myopia.
METHODS: A retrospective chart review of children presenting with large clear cornea to the pediatric ophthalmology unit of the ophthalmology department of Alexandria Main University Hospital in the period from March 2011 to December 2020 was conducted. A large clear cornea was defined as a horizontal white-to-white corneal diameter (as measured by calipers) greater than 12 mm. Glaucoma was diagnosed according to the childhood glaucoma research network (CGRN) criteria and the axial length was used to filter out eyes with large clear corneas due to congenital high myopia.
RESULTS: Out of 120 eyes of 91 (58 males) children a total of 76 eyes of 67 (41 males) children were diagnosed with glaucoma and 44 eyes of 24 (17 males) children (36.7%) did not suffer glaucoma. Out of these, 30 eyes were classified as myopia and 14 eyes as congenital megalocornea.
CONCLUSIONS: More than one third of eyes presenting with large clear corneas may not have glaucoma, and almost two thirds of these eyes (that are not suffering from glaucoma) demonstrate axial myopia.
摘要：
目的:在足月婴儿中,大于2个标准偏差(9.8mm)或大于11mm的水平角膜直径定义为巨角膜(本文称为大透明角膜)。本研究的目的是报告患有无青光眼的大透明角膜的儿童的发病率和临床特征。
方法：对2011年3月至2020年12月期间到亚历山大大帝医院眼科儿科眼科就诊的大透明角膜患儿进行回顾性分析。大的透明角膜被定义为水平的白色到白色角膜直径(如通过卡尺测量的)大于12mm。根据儿童青光眼研究网络（CGRN）标准诊断青光眼，并且眼轴长度用于过滤由于先天性高度近视而具有大透明角膜的眼睛。
结果：在91名(58名男性)儿童的120只眼中，67名(41名男性)儿童的76只眼被诊断为青光眼，24名(17名男性)儿童的44只眼(36.7%)没有青光眼。在这些中，近视30只眼，先天性巨角膜14只眼。
结论：1/3以上出现大的透明角膜的眼睛可能没有青光眼，这些眼睛中几乎有三分之二（没有患有青光眼）表现出轴性近视。
方法：对2011年3月至2020年12月期间到亚历山大大帝医院眼科儿科眼科就诊的大透明角膜患儿进行回顾性分析。大的透明角膜被定义为水平的白色到白色角膜直径(如通过卡尺测量的)大于12mm。根据儿童青光眼研究网络（CGRN）标准诊断青光眼，并且眼轴长度用于过滤由于先天性高度近视而具有大透明角膜的眼睛。
结果：在91名(58名男性)儿童的120只眼中，67名(41名男性)儿童的76只眼被诊断为青光眼，24名(17名男性)儿童的44只眼(36.7%)没有青光眼。在这些中，近视30只眼，先天性巨角膜14只眼。
结论：1/3以上出现大的透明角膜的眼睛可能没有青光眼，这些眼睛中几乎有三分之二（没有患有青光眼）表现出轴性近视。
