Abstract：
Perfluoro octane sulfonate (PFOS) and cadmium (Cd) are toxic elements in the environment. As a micronutrient trace element, selenium (Se) can mitigate the adverse effects induced by PFOS and Cd. However, few studies have examined the correlation between Se, PFOS and Cd in fish. The present study focused on the antagonistic effects of Se on PFOS+Cd-induced accumulation in the liver of zebrafish. The fish was exposed to PFOS (0.08mg/L), Cd (1mg/L), PFOS+ Cd (0.08 mg/L PFOS+1 mg/L Cd), L-Se (0.07mg/L Sodium selenite +0.08mg/L PFOS+1mg/L Cd), M-Se (0.35mg/L Sodium selenite + 0.08mg/L PFOS+ 1 mg/L Cd), H-Se (1.75 mg/L Sodium selenite + 0.08 mg/L PFOS+ 1mg/L Cd) for 14d. The addition of selenium to fish exposed to PFOS and Cd has been found to have significant positive effects. Specifically, selenium treatments can alleviate the adverse effects of PFOS and Cd on fish growth, with a 23.10% improvement observed with the addition of T6 compared to T4. In addition, selenium can alleviate the negative effects of PFOS and Cd on antioxidant enzymes in zebrafish liver, thus reducing the liver toxicity caused by PFOS and Cd. Overall, the supplementation of selenium can reduce the health risks to fish and mitigate the injuries caused by PFOS and Cd in zebrafish.
摘要：
全氟辛烷磺酸（PFOS）和镉（Cd）是环境中的有毒元素。作为一种微量营养素微量元素，硒（Se）可以减轻PFOS和Cd引起的不利影响。然而,很少有研究检查硒之间的相关性，鱼类中的全氟辛烷磺酸和Cd。本研究主要研究硒对PFOS+Cd诱导斑马鱼肝脏积累的拮抗作用。鱼暴露于全氟辛烷磺酸（0.08mg/L），Cd（1mg/L），全氟辛烷磺酸+镉(0.08毫克/升全氟辛烷磺酸+1毫克/升镉)，L-Se(0.07mg/L亚硒酸钠+0.08mg/LPFOS+1mg/LCd),M-Se(0.35mg/L亚硒酸钠+0.08mg/LPFOS+1mg/LCd),H-Se(1.75mg/L亚硒酸钠+0.08mg/LPFOS+1mg/LCd)连续14d。已发现向暴露于PFOS和Cd的鱼中添加硒具有显着的积极作用。具体来说,硒处理可以减轻全氟辛烷磺酸和镉对鱼类生长的不利影响，与T4相比,在添加T6的情况下观察到23.10%的改善。此外,硒可以减轻PFOS和Cd对斑马鱼肝脏抗氧化酶的负面影响,从而降低了由全氟辛烷磺酸和Cd引起的肝毒性。总的来说,补充硒可以降低斑马鱼对鱼类的健康风险，减轻全氟辛烷磺酸和镉对斑马鱼的伤害。
